Synthetic Organic Electrochemistry
Electrochemistry represents a powerful tool within synthetic organic chemistry. E.g., electrodes can be used to generate highly reactive and short-lived species, which are otherwise unfeasible to create/use in synthetic organic chemistry. Moreover, the current at these electrodes can be used for monitoring the presence of species and for probing reaction mechanisms.
As a member of the NSF funded Center for Chemical Innovation: Center for Synthetic Organic Electrochemistry, the White group are at the forefront of an effort to use electrochemistry to research enabling, green, safe, and economic reactions and to develop a deep fundamental understanding of how these reactions proceed. In doing this, we employ a range of electrochemical techniques from basic, e.g., voltammetry, to more advanced, such as, scanning electrochemical microscopy (SECM), which allow us to probe fast reactions and short time-scales.
References:
Oxidation by Reduction: Efficient and Selective Oxidation of Alcohols by the Electrocatalytic
Reduction of Peroxydisulfate
S. Hosseini, J. N. Janusz, M. Tanwar, A. D. Pendergast, M. Neurock, and H. S. White
J. Am. Chem. Soc. 2022, 144, 46, 21103–21115
Electrochemical Reduction of [Ni(Mebpy)3]2+. Elucidation of the Redox Mechanism by
Cyclic Voltammetry and Steady-State Voltammetry in Low Ionic Strength Solutions.
ChemElectroChem. 2020. 7(6), 1473-1479
Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications
Y. Kawamata, J. C. Vantourout, D. P. Hickey, P. Bai, L. Chen, Q. Hou, W. Qiao, K.
Barman, M. A. Edwards, A. F. Garrido-Castro, J. N. deGruyter, H. Nakamura, K. W. Knouse,
C. Qin, K. J. Clay, D. Bao, C. Li, J. T. Starr, C. Garcia-Irizarry, N. Sach, H. S.
White, M. Neurock, S. D. Minteer, and P. S. Baran
J. Am. Chem. Soc., Just Accepted Manuscript. DOI: 10.1021/jacs.9b01886