Analytical, Energy, and Biophysical Chemistry (and Nanobubbles)

White Research Group

The White group is an interdisciplinary team that applies principles grounded in electrochemistry to advance understanding of a wide variety of physical systems. Systems currently investigated within the group span the physical, analytical and biological sciences. These include nano-pore/pipette based sensing, measuring and delivery of nanoscale particles; protein ion channel electrical measurements of nucleic acids; theoretical and electrochemical scanned probe investigations of solid-state batteries; experimental measurements and theoretical analysis of ionic transport in confined geometries; and fundamental studies of electrochemically generated nanobubbles. See below for our latest publications, and the research section for more details on our research interests.

Latest Publications:

Observing Transient Bipolar Electrochemical Coupling on Single Nanoparticles Translocating through a Nanopore

Observing Transient Bipolar Electrochemical Coupling on Single Nanoparticles Translocating through a Nanopore

C. Han, R. Hao, Y. Fan, M. A. Edwards, H. Gao, and B. Zhang

Langmuir, Just Accepted Manuscript. DOI: 10.1021/acs.langmuir.9b01255


 

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Electrochemically Driven, Ni-Catalyzed Aryl Amination: Scope, Mechanism, and Applications

Y. Kawamata, J. C. Vantourout, D. P. Hickey, P. Bai, L. Chen, Q. Hou, W. Qiao, K. Barman, M. A. Edwards, A. F. Garrido-Castro, J. N. deGruyter, H. Nakamura, K. W. Knouse, C. Qin, K. J. Clay, D. Bao, C. Li, J. T. Starr, C. Garcia-Irizarry, N. Sach, H. S. White, M. Neurock, S. D. Minteer, and P. S. Baran

J. Am. Chem. Soc., 2019, 141 (15), pp 6392–6402


 

Voltammetric Determination of the Stochastic Formation Rate and Geometry of Individual H2, N2, and O2 Bubble Nuclei

Voltammetric Determination of the Stochastic Formation Rate and Geometry of Individual H2, N2, and O2 Bubble Nuclei

M. A. Edwards, H. S. White, H. Ren

ACS Nano, Article ASAP. DOI: 10.1021/acsnano.9b01015

 


 

γ-Hemolysin Nanopore Is Sensitive to Guanine-to-Inosine Substitutions in Double-Stranded DNA at the Single-Molecule Level

γ-Hemolysin Nanopore Is Sensitive to Guanine-to-Inosine Substitutions in Double-Stranded DNA at the Single-Molecule Level

Cherie S. Tan, Aaron M. Fleming , Hang Ren , Cynthia J. Burrows, and Henry S. White

J. Am. Chem. Soc., 2018140 (43), pp 14224–14234.


 

Nanoscale electrochemical kinetics & dynamics: the challenges and opportunities of single-entity measurements

Nanoscale electrochemical kinetics & dynamics: the challenges and opportunities of single-entity measurements

Martin Edwards, Donald Robinson, Hang Ren, Cameron Cheyne, Cherie Tan, and Henry S. White.

Faraday Discuss., 2018, 210, 9-28.


 

Effects of Instrumental Filters on Electrochemical Measurement of Single‐Nanoparticle Collision Dynamics

Effects of Instrumental Filters on Electrochemical Measurement of Single‐Nanoparticle Collision Dynamics

Donald Robinson, Martin A. Edwards, Hang Ren, and Henry S. White

ChemElectroChem,2018, 5, 3059.


 

The Nucleation Rate of Single O2 Nanobubbles at Pt Nanoelectrodes

The Nucleation Rate of Single O2 Nanobubbles at Pt Nanoelectrodes

Álvaro Moreno Soto, Sean R. German, Hang Ren, Devaraj van der Meer, Detlef Lohse, Martin A. Edwards, and Henry S. White

Langmuir, 2018, 34 (25), pp 7309–7318.


 

Critical Nuclei Size, Rate, and Activation Energy of H2 Gas Nucleation

Critical Nuclei Size, Rate, and Activation Energy of H2 Gas Nucleation

Sean R. German, Martin A. Edwards, Hang Ren, and Henry S. White

J. Am. Chem. Soc., 2018, 140 (11), pp 4047–4053.


 

Single-Molecule Titration in a Protein Nanopore

Single-Molecule Titration in a Protein Nanoreactor Reveals the Protonation/Deprotonation Mechanism of a C:C Mismatch in DNA

Hang Ren, Cameron G. Cheyne, Aaron M. Fleming, Cythia J. Burrows, and Henry S. White

J. Am. Chem. Soc., 2018, 140155153-5160.


 

Flat and Nano-Tip Conical Electrodes during Vesicle Impact Electrochemical Cytometry

Nanopore Opening at Flat and Nano-Tip Conical Electrodes during Vesicle Impact Electrochemical Cytometry

Xianchan Li, Lin Ren, Johan Dunevall, Daixin Ye, Henry S. White, Martin A. Edwards, and Andrew G. Ewing

ACS Nano, 2018, 12(3):3010-3019.


 

Nanopore Analysis of the 5-Guanidinohydantoin to Iminoallantoin Isomerization in Duplex DNA

Nanopore Analysis of the 5-Guanidinohydantoin to Iminoallantoin Isomerization in Duplex DNA

Tao Zeng, Aaron M. Fleming, Yun Ding, Hang Ren, Henry S. White, Cynthia J. Burrows

J. Org. Chem., 2018, 83 (7), pp 3973–3978.


 

Single Ag Nanoparticle Collisions within a Dual-Electrode Micro-Gap Cell

Single Ag Nanoparticle Collisions within a Dual-Electrode Micro-Gap Cell

Kim McKelvey, Donald A. Robinson, Nicholas J. Vitti, Martin A. Edwards, Henry S. White

Faraday Discuss., 2018, 210, 189-200.


 

Critical Nuclei Size, Rate, and Activation Energy of H2 Gas Nucleation

Critical Nuclei Size, Rate, and Activation Energy of H2 Gas Nucleation

Sean R. German, Martin A. Edwards, Hang Ren, Henry S. White

J. Am. Chem. Soc., 2018, 140 (11), pp 4047–4053.


 

Selective increase in CO2 electroreduction activity at grain-boundary surface terminations

Selective increase in CO2 electroreduction activity at grain-boundary surface terminations

R. G. Mariano, K. McKelvey, H. S. White, M. W. Kanan

Science, 358 (2017) 1187-1192.


 

Exploring the suitability of different electrode materials for hypochlorite quantification at high concentration in alkaline solutions

Exploring the suitability of different electrode materials for hypochlorite quantification at high concentration in alkaline solutions

R. E.P. Meyler, M. A. Edwards, J. V. Macpherson

Electrochemistry Communications, 86 (2018) 21-25.


 

Collision Dynamics During the Electrooxidation of Individual Silver Nanoparticles

Collision Dynamics During the Electrooxidation of Individual Silver Nanoparticles

D. A Robinson, Y. Liu, M. A. Edwards, N. J. Vitti, S. M. Oja, B. Zhang, H. S. White

J. Am. Chem. Soc., (2017) 139, 46, 16923-16931.


 

Redox cycling in nanogap electrochemical cells

Redox Cycling in Nanogap Electrochemical Cells

H. S. White, K. McKelvey
Current Opinion in Electrochemistry, 2017, 7, 48-53.


 

Three-Dimensional Super-resolution Imaging of Single Nanoparticles Delivered by Pipettes

Three-Dimensional Super-Resolution Imaging of Single Nanoparticles Delivered by Pipettes

Y. Yu, V. Sundaresan, S. Bandyopadhyay, Y. Zhang, M. A. Edwards, K. McKelvey, H. S. White, K. A. Willets.
ACS Nano, 2017, 11 (10), pp 10529–10538.


 

Nanoparticle Collision at a Gold Nanoband Electrode

Collision and Oxidation of Silver Nanoparticles on a Gold Nanoband Electrode

F. Zhang, M. Edwards, R. Hao, H. S. White, B. Zhang
J. Phys. Chem. C, 2017121 (42), pp 23564–23573.


Microscale 2.5D Batteries

Microscale 2.5D Batteries

K. McKelvey, A. A. Talin, B. Dunn, and H. S. White
Journal of The Electrochemical Society, 2017, 164(12), A2500-2503.


 

Nanopipettes as a Tool for Single Nanoparticle Electrochemistry

Nanopipettes as a Tool for Single Nanoparticle Electrochemistry 

K. McKelvey, S. R. German, Y. Zhang, H. S. White, and M. A. Edwards
Current Opinion in Electrochemistry, 2017, 6(1), 4-9.


ACS Spotlight

Electrochemical Generation of Individual O2 Nanobubbles via H2O2 Oxidation

Featured in Spotlights, a new initiative of The Journal of Physical Chemistry Letters designed to expand awareness for physical chemistry by presenting accessible plain-language summaries of select articles in each issue.

H. Ren, S. R. German, M. A. Edwards, Q. Chen, and H. S. White


 

 

Electrochemical Generation of Individual O2 Nanobubbles via H2O2 Oxidation 

H. Ren, S. R. German, M. A. Edwards, Q. Chen, and H. S. White
J. Phys. Chem. Lett., 2017, 8, 2450-2454.


TOC: Zeng 2017

Interrogation of Base Pairing of the Spiroiminodihydantoin Diastereomers Using the α-Hemolysin Latch

Tao Zeng, Aaron M. Fleming, Yun Ding, Henry S. White, and Cynthia J. Burrows 
Biochemistry, 2017, 56 (11), 1596–1603.


TOC: Kinetics of T3

Dynamics of a DNA Mismatch Site Held in Confinement Discriminate Epigenetic Modifications of Cytosine

Robert P. Johnson, Aaron M. Fleming, Rukshan T. Perera, Cynthia J. Burrows, and Henry S. White
J. Am. Chem. Soc., 2017, 139 (7), 2750–2756.


TOC: Kinetics of T3

The dynamic steady state of an electrochemically generated nanobubble

Yuwen Liu, Martin A. Edwards, Sean R. German, Qianjin Chen, and Henry S. White
Langmuir, 2017, 33 (8), 1845–1853.


TOC: Kinetics of T3

Observation of Multipeak Collision Behavior during the Electro-Oxidation of Single Ag Nanoparticles

Stephen M Oja, Donald A. Robinson, Nicholas J. Vitti, Martin A. Edwards, Yuwen Liu, Henry S. White, and Bo Zhang
J. Am. Chem. Soc., 2017, 139 (2), 708–718.


TOC: Kinetics of T3

Kinetics of T3-DNA Ligase-Catalyzed Phosphodiester Bond Formation Measured Using the α-Hemolysin Nanopore

Cherie S. Tan, Jan Riedl, Aaron M. Fleming, Cynthia J. Burrows, and Henry S. White
ACS Nano, 201610 (12), 11127–11135.


TOC: 3D LiPON Battery

Fabrication, Testing, and Simulation of All-Solid-State Three Dimensional Li-Ion Batteries

A. Alec Talin, Dmitry Ruzmetov, Andrei Kolmakov, Kim McKelvey, Nicholas Ware, Farid El Gabaly, Bruce S. Dunn, and Henry S. White
ACS Appl. Mater. Interfaces, 2016, 8 (47), 32385–32391.


TOC: Nanopore2016

Voltage-Rectified Current and Fluid Flow in Conical Nanopores

Wen-Jie Lan, Martin A. Edwards, Long Luo, Rukshan T. Perera, Xiaojian Wu, Charles R. Martin, and Henry S. White
Acc. Chem. Res., 201649 (11), 2605–2613.


TOC: Laplace PressureLaplace Pressure of Individual H2 Nanobubbles from Pressure–Addition Electrochemistry

Sean R. German, Martin A. Edwards, Qianjin Chen, and Henry S. White
Nano. Lett., 201616 (10), 6691–6694.


TOC: PS NP Delivery J Phys Chem Lett 2016Resistive Pulse Delivery of Single Nanoparticles to Electrochemical Interfaces

Kim McKelvey, Martin A. Edwards, and Henry S. White
J. Phys. Chem. Lett., 2016, 7, 3920–3924. 


TOC: Nanogap J Phys Chem C 2016Redox Cycling in Nanogap Electrochemical Cells. The Role of Electrostatics in Determining the Cell Response

Qianjin Chen, Kim McKelvey, Martin A. Edwards, and Henry S. White
J. Phys. Chem. C, 2016, 120 (31), 17251–17260. 


 

Last Updated: 5/13/19