Publications

Refereed Journal Articles


55. Kopljar, I.; Labro, A. J.; Cuypers, E.; Johnson, H. W. B.; Rainier, J. D.; Tytgat, J.; Snyders, D. J. "A Novel Toxin Binding Site in Voltage Gated Potassium Chennels Revealed by the Marine Toxin Gambierol," Proc. Nat. Acad. Sci.2009 in press.

54. Coryell, M.; Wunsch, A.; Haenfler, J.; Allen, J.; Schnizler, M.; Ziemann, A.; Cook, M.; Dunning, J.; Price, M.; Rainier, J.D.; Liu, Z.; Light, A.; Langbenh, D.; Wemmie, J. "Acid-sensing ion channel-1a in the amygdala, a novel therapeutic target in depression-related behavior," J. Neurosci.2009, 29, 5481-5388.

53. Hayes, S. G.; McCord, J. L.; Rainier, J.; Liu, Z.; Kaufman, M.P. "Role Played by Acid-Sensitive Ion Channels in Evoking the Exercise Pressor Reflex," Am. J. Phys.2008, 295, H1720-H1725.

52. Zhang, Y.; Rainier, J. D. “Two Directional Olefinic-Ester and Diene Ring-Closing Metathesis using Reduced Ti Alkylidenes. A Rapid Entry into Polycyclic Ether Skeletons,” Org. Lett. 2009, 11, 237.

51. Rohanna, J. C.; Rainier, J. D. “Olefinic-Lactone Cyclizations to Macrocycles,” Org. Lett. 2009, 11, 493.

50. Espejo, V. R.; Rainier, J. D. “An Expeditious Synthesis of C(3)-N(1') Heterodimeric Indolines,” J. Am. Chem. Soc. 2008, 130, 12894

49. Osei Akoto, C.; Rainier, J. D. “Harnessing Glycal Epoxide Rearrangements. The Generation of the A,B-, E,F-, and I,J-Rings of Adriatoxin” Angew. Chem. Int. Ed. 2008, 47, 8055.

48. Boyarskikh, V.; Nyong, A.; Rainier, J. D. “Highly Diastereoselective Sulfonium Ylide Rearrangements to Quaternary Substituted Indolines,” Angew. Chem. Int. Ed. 2008, 47, 5374.

47. Light, A.R.; Hughen, R.W.; Zhang, Z.; Rainier, J.; Liu, Z.; Lee, J. "Dorsal root ganglion neurons innervating skeletal muscle respond to physiological combinations of protons, ATP and lactate mediated by ASIC, P2X and TRPV1," J. Neurophysiol. 2008, 100, 1169.

46. Cuypers, E.; Abdel-Mottaleb, Y.; Rainier, J. D.; Tytgat, J. “Gambierol, A Toxicon Produced by the Gambierdiscus toxicus, is a Potent blocker of Voltage-Gated Potassium Channels,” Toxicon, 2008, 51, 974.

45. Cao, Z.; George, J.; Gerwick, W. H.; Baden, D. G.; Rainier, J. D.; Murray, T. F. “Influence of Lipid Soluble Gating Modifier Toxins on Sodium Influx in Neocortical Neurons,” J. Pharm. Exp. Therap. 2008, 362, 604.

44. Iyer, K.; Rainier, J. D. “Olefinic-Ester and Diene Ring-Closing Metathesis Using a Reduced Titanium Alkylidene,” J. Am. Chem. Soc. 2007, 129, 12604.

43. Cuypers, E.; Yanagihara, A.; Rainier, J. D.; Tytgat, J. “TRPV1 as a key determinant in ciguatera and neurotoxic shellfish poisoning,” Biochem. Biophys. Res. Commun. 2007361, 214.

42. LePage, K. T.; Rainier, J. D.; Johnson, H. W. B.; Baden, D. G.; Murray, T. F. “Gambierol Acts as a Functional Antagonis of Neurotoxin Site 5 on Voltage-Gated Sodium Channels in Cerebellar Granule Neurons,” J. Pharm. Exp. Therap. 2007, 323, 174.

41. Roberts, S. W.; Rainier, J. D. “The Synthesis of an A-E Gambieric Acid Subunit using a C-Clycoside Centered Strategy,” Org. Lett. 2007, 9, 227.

40. Orendt, A. M.; Roberts, S. W.; Rainier, J. D. “The Role of Asynchronous Bond Formation in the Diastereoselective Epoxidation of Cyclic Enol Ethers: A Density Functional Theory Study,” J. Org. Chem. 2006, 71, 5565. PDF

39. Sabahi, A.; Novikov, A.; Rainier, J. D. “2-Thioindoles as Precursors to Spiro-Fused Indolines: Synthesis of (±)-Dehaloperophoramidine,” Angew. Chem. Int. Ed. 2006, 45, 4317. PDF

38. Majumder, U.; Cox, J. M.; Johnson, H. W. B.; Rainier, J. D. “The Total Synthesis of Gambierol. The Generation of the A-C and F-H Subunits Using a C-Glycoside Centered Strategy,” Chem. Eur. J. 2006, 12, 1736. PDF

37. Johnson, H. W. B.; Majumder, U.; Rainier, J. D. “The Total Synthesis of Gambierol. Subunit Coupling and Completion,” Chem. Eur. J. 2006, 12, 1747. PDF

36. Liu, Z.; Rainier, J. D. “Ring-Opening/ring-Closing Metathesis (RORCM) Reactions of 7-Azanorbornene Derivatives. An Entry into Perhydroindolines,” Org. Lett. 2006, 8, 459. PDF

35. Majumder, U.; Rainier, J. D. “Olefinic-ester cyclizations using Takai-Utimoto reduced titanium alkylidenes,” Tetrahedron Lett. 2005, 46, 7209. PDF

34. Roberts, S. W.; Rainier, J. D. Substitution and Remote Protecting Group Influence on the Oxidation/Addition of a-Substituted 1,2-Anhydroglycosides: A Novel Entry into C-Ketosides,” Org. Lett. 2005, 7, 1141. PDF

33. Johnson, H. W. B.; Majumder, U.; Rainier, J. D.* “The Total Synthesis of Gambierol,” J. Am. Chem. Soc. 2005, 127, 848. PDF

32. Liu, Z.; Rainier, J. D. “Regioselective Ring-Opening/Cross-Metathesis Reactions of Norbornene Derivatives with Electron Rich Olefins,” Org. Lett. 2005, 7, 131. PDF

31. Nyong, A.; Rainier, J. D. “The diastereoselective synthesis of quaternary substituted thioindolines from sulfur ylide intermediates,” J. Org. Chem. 2005, 70, 746

. PDF

30. Weerasakere, M.; Liu, Z.; Rainier, J. D. “Highly Regioselective Ring-Opening/Cross-Metathesis Reactions of 2-Sulfonylnorbornene Derivatives,” Org. Lett. 2004, 6, 1625. PDF

29. Smith, A. B., III; Kanoh, N.; Ishiyama, H.; Minakawa, N.; Rainier, J. D.; Hartz, R. A.; Cho, Y. S.; Cui, H.; Moser, W. H. “The Total Synthesis of (-)-Penitrem D,” J. Am. Chem. Soc. 2003, 125, 8228.

28. Novikov, A. N.; Kennedy, A. R.; Rainier, J. D.§ “Sulfur Ylide Initiated Thioclaisen Rearrangements. The Synthesis of Highly Substituted Indolines,” J. Org. Chem. 2003, 68, 993-996. PDF

27. Novikov, A. N.; Sabahi, A.; Nyong, A. M.; Rainier, J. D.§ “The diastereoselective Synthesis of Quaternary Substituted Indolines from Sulfur Ylide Intermediates,” Tetrahedron Asymm. 200314, 911-915. PDF

26. Majumder, U.; Cox, J. M.; Rainier, J. D.§ “Synthesis of an F-H Gambierol Subunit Using a C-Glycoside Centered Strategy,” Org. Lett. 20035, 913-916. PDF

25. Weerasakere, M.; Xu, Q.; Rainier, J. D.§ “An Anionic Condensation and Fragmentation Approach to 3-Pyrrolines” Tetrahedron Lett. 2002, 43, 8913. PDF

24. Allwein, S. P.; Cox, J. M.; Howard, B., E.; Johnson, H., W, B.; Rainier, J. D.§ “C-Glycosides to Fused Polycyclic Ethers” Tetrahedron 2002, 58, 1997. PDF

23. Imbriglio, J. E.; Rainier, J. D.§ “[2+2+1] Cycloadditions of Ynol Ethers. The Synthesis of Iron Complexes of 3-Alkoxycyclopentadienones” Tetrahedron Lett. 2001, 42, 6987. PDF

22. Cox, J. M.; Rainier, J. D. “C-Glycosides to Fused Polycyclic Ethers. An Efficient Entry into the A-D Ring System of Gambierol,” Org. Lett. 2001, 3, 2919. PDF

21. Xu, Q.; Weeresakare, M.; Rainier, J. D. “Anionic Ring Expansion Reactions of Oxabicyclo[4.2.1]heptenones. An Efficient Entry into the Carbon Framework of Oxygenated Cembranoids,” Tetrahedron 2001, 57, 8029. PDF

20. Kennedy, A. R.; Taday, M. H.; Rainier, J. D. “The Use of Sulfur Ylides in the Synthesis of Substituted Indoles,” Org. Lett.2001, 3, 2407. PDF

19. Rainier, J. D.; Cox, J. M.; Allwein, S. P. "Enol Ether-Olefin Ring Closing Metathesis Using the Grubbs Ruthenium Imidazole Catalyst," Tetrahedron Lett. 2001, 42, 179.PDF

18. Rainier, J. D.; Allwein, S. P.; Cox, J. M. "C-Glycosides to Fused Polyethers. A Formal Synthesis of (±)-Hemibrevetoxin B," J. Org. Chem. 2001, 66, 1380.PDF

17. Rainier, J. D. and Smith, A. B., III "Polyene Cyclizations to Indole Diterpenes. The First Synthesis of (+)-Emindole SA Using a Biomimetic Approach," Tetrahedron Lett.2000, 41, 9419.

16. Rainier, J. D.; Kennedy, A. R. "Cascades to Substituted Indoles," J. Org. Chem.2000, 65, 6213. PDF

15. Rainier, J. D.; Imbriglio, J. I. "The Synthesis and Chemoselective Reactivity of 3-Aminocyclopentadienones," J. Org. Chem. 2000, 65, 7272. PDF

14. Rainier, J. D.; Cox, J. M. "Aluminum and Boron Mediated C-Glycoside Synthesis From 1,2-Anhydroglycosides," Org. Lett2000, 2, 2707. PDF

13. Rainier, J. D.; Allwein, S. P.; Cox, J. M. “A Highly Efficient Synthesis of the Hemibrevetoxin B Ring System,” Org. Lett. 2000, 2, 231-234. PDF

12. Rainier, J. D.; Imbriglio, J. E. “The Synthesis and Chemoselective Reactivity of 3-Aminocyclopentadienones,” Org. Lett.1999, 1, 2037-2039. PDF

11. Rainier, J. D.; Xu, Q. “Anionic Two-Carbon Ring Expansions of Oxabicyclo[2.2.1]heptenes and Oxabicyclo[4.2.1]nonenes,” Org. Lett.1999, 1, 1161-1163. PDF

10. Smith, A. B., III; Kanoh, N.; Minakawa, N.; Rainier, J. D.; Blase, F. R.; Hartz, R. A. “Tremorgenic Indole Alkaloids. Studies Directed Towards the Assembly of the A, F, and I Rings of Penitrem D: Observation of an Unexpected Stereochemical Outcome,” Org. Lett.1999, 1,1263-1266.

9. Rainier, J. D.; Kennedy, A. R.; Chase E. “An Isonitrile-Alkyne Cascade to Di-Substituted Indoles,” Tetrahedron Lett.1999, 40, 6325-6327. PDF

8. Rainier, J. D.; Xu, Q. “A Novel Anionic Condensation, Fragmentation, and Elimination Reaction of Bicyclo[2.2.1]heptenone Ring Systems,” Org. Lett.1999, 1, 27.

7. Rainier, J. D.; Allwein, S. P."A Highly Efficient Iterative Approach to Fused Ether Ring Systems," Tetrahedron Lett.1998, 39, 9601-9604. PDF

6. Rainier, J. D.; Allwein, S. P "An Iterative Approach to Fused Ether Ring Systems," J. Org. Chem.1998, 63, 5310-5311. PDF

5. Smith, A. B., III; Hartz, R. A.; Spoors, P. G; Rainier, J. D. "Tremorgenic Indole Alkaloid Studies. 10. An Improved Asymmetric Synthesis of a Tricyclic Common Intermediate," Israel J. Chem.1997, 37, 69-90.

4. Angle, S. R.; Rainier, J. D.; Woytowicz, C. "Synthesis and Chemistry of Quinone Methide Models for the Anthracycline Antitumor Antibiotics," J. Org. Chem. 1997, 62, 5884-5892.

3. Angle, S. R.; Arnaiz, D. O.; Boyce, J. P.; Frutos, R. P.; Louie, M. S.; Mattson-Arnaiz, H. L.; Rainier, J. D.; Turnbull, K. D.; Yang, W. "Formation of Carbon-Carbon Bonds via Quinone Methide-Initiated Cyclization Reactions," J. Org. Chem.1994, 59, 6322-6337.

2. Angle, S. R.; Rainier, J. D. "Reductive Cyclization of Quinone Methides," J. Org. Chem.1992, 57, 6883-6890.

1. Nakayama, K.; Rainier, J. D."Synthesis of (2R, 3R)-1,4-Dimethoxy-1,1,4,4-Tetraphenyl-2,3-Butanediol: A New C2-Symmetric Vicinal Diol From Dimethyl L-Tartrate," Tetrahedron1990, 46, 4165-4170.

Book Chapters


3. Iyer, K.; Rainier, J. D. "Product Class 1: Synthesis of 5-, 6-, and Larger Oxa-3-Cycloalkenes From Other Cyclic Ethers," in Science of Synthesis; Forsyth, C. J. Ed.; Thieme, Stuttgart; (2009), vol. 37, pp. 555-579.

2. Roberts, S.; Rainier, J. D. "Product Class 1: Synthesis of 5-, 6-, and Larger Oxa-3-Cycloalkenes by Ring Closing Metathesis," in Science of Synthesis; Forsyth, C. J. Ed.; Thieme, Stuttgart; (2009), vol. 37, pp. 531-551.

1. Rainier, J. D. "Application of C-Clycosides in the Total Synthesis of (-)-Gambierol," in Strategies and Tactics in Organic Synthesis, M. Harmata (Ed.); Elsevier, Amsterdam; (2008), vol. 7, pp. 154-216.