Current Group

 Cross, Jeffrey (Jeff)

Forsyth, Brandon

Neti, Syam

Pan, Jian-Jung (JJ)

Ramamoorthy, Gurusankar (Guru)

Slessor, Kate

Alumni

Postdoctoral Researchers

Professor Oliver J. Muscio

Murray State College, Department of Chemistry

Professor Georges Wolzcunowicz

University of Geneva, Department of Medical Biochemistry

Professor Liliana Chayet

Universidad de Chile, Lab de Bioquimica

Dr. Lai-Su Lee Yeh

Dr. Joseph Craig Argyle

Physician, private practice

Dr. John Roberts

Hoffman-LaRoche, Medicinal Chemistry Research

Professor George Gurria

University of Wisconsin

Dr. F. Mark Laskovics

Girindus American Inc.

Dr. Chi-Hsin R. King

Albany Molecular Research, Inc.

Dr. Ronda M. Sandifer

Reed College, Portland, OR

Dr. Wendy I. Noall

Eli Lilly

Professor Tadashi Aoki

Hiroshima University, Suzugamine Women's College

Dr. Desiree L. Bartlett

Stauffer Chemiceal

Dr. Sonja Klein

Universitat Mainz, Germany

Dr. Vyas M. Dixit

AnalChem Pvt Ltd

Dr. Lawrence Perez

Novartis Institutes for Biomedical Research

Dr. Mary M. Sherman

Merck-Frosst Canada

Dr. Matt S. Anderson

Merck Research Laboratories, Department of Biochemistry

Dr. R. Michael Lawrence

Bristol-Myers Squibb

Dr. Ian P. Street

Royal Melbourne Hospital

Dr. Mark Brown

Echelon Biosciences, Inc.

Professor Matthias Mayer

University of Heidelberg, Germany

Dr. Shivanand K. Math

IBC-Advanced Technologies

Dr. Donglu Zhang

Bristol Myers Squibb

Professor Dirk Iwata-Reuyl

Portland State University, Department of Chemistry

Dr. Dan Rogers

CombiChem

Dr. Linsheng Song

Bio-Technical Resources

Dr. William G. Stirtan

Bayer Corp.

Assistant Professor Philip Proteau

Oregon State University, College of Pharmacy, Corvallis, OR

Dr. David Witter

Merck Research Laboratories

Dr. Jeffrey Moore

Abbott Laboratories

Dr. David Owen

Starpharma Pty Ltd

Dr. Barbara Frey

Universitaet Karlsruhe, Institut fuer Organische Chemie,

Dr. Jeffrey R. Mathis

Software Engineer, Perkin-Elmer Informatics, Inc

Dr. Kathleen Rising Manna

Bellarmine University

Dr. Brenda Kellogg

Immunogen

Dr. David Rozema

Mirus Inc.

Dr. Lance E. Steward

Allergan

Professor Kurt Dolence

University of Wyoming

Dr. Julia Dolence

University of Wyoming

Dr. Frederick M. Hahn

USDA, Albany, NY

Dr. Aquilles Leyes

Merck Corp

Andrea Hemmerlin

University of Strasbourg, France

Dr. Julie L. Kadrmas

University of Utah, Huntsman Cancer Institute

Dr. Tom Siepmann

Registered Patent Attorney, Birch, Stewart, Kolasch & Birch, L.L.P

Dr. Christopher M. Harris

Abbott Bioresearch Center, Worcester MA

Dr. Jason McCary

Battelle Dugway Operations, Dugway UT

Dr. Weiping Li

Pharmadigm, Inc., Salt Lake City UT

Dr. Hans Erickson

Immunogen Inc., Cambridge MA

Dr. Christina Carrigan

Immunogen, Inc.

Dr. Vallabh Desai

Biocon India limited, India

Dr. Cecile Gauchet

ENDOTIS Pharma

Professor Christian Lherbet

University Paul Sabatier, Toulouse, France

Sungwon Lee

LS9

Joel Walker

Acenta Discovery

G. Labadie

Argentina

Steve Rothman

Dupont

H.V. Thulasiram

National Chemical Laboratory

Wenyun Gao

College of Life Sciences, Northwest University, China

Owen McDougall

Boise State University

Rajesh Viswanathan

Case Western University, Cleveland, OH

Graduate Students

PhDs

Dr. Richard B. Anderson, 1973

"Protonation of Pyrimidines"

Dr. Charles J. Spillner, Jr.; 1973

"A Model Substituted Cyclopropanemethyl Cation"

Solano Community College

Dr. Gary D. Frederick, 1975

"Protonation Studies of Pyrimidines"

Brigham Young University, Hawaii

Dr. John M. Hughes, 1975

"Model Studies of the Biosynthesis of Non-Head-to-Tail Terpenes"

Hewlett Packard

Dr. Clyde L. Livingston, 1978

"Nuclear Magnetic Resonance Studies of Nucleic Acid Interactions."

Monsanto Agricultural Company

Professor Dennis M. Satterwhite, 1979

"Studies on the Mechanisms of the Reactions of Isopentenyl Pyrophosphate Isomerase and Farnesyl Pyrophosphate Synthetase"

Lewis-Clark State University

Dr. Richard Gaughan, 1980

"The Synthesis of Terpene Analogs"

Exxon Research & Engineering Co

Dr. Chi-Hsin R. King, 1980

"Model Studies of Terpene Biosynthesis. The Stereochemistry of Intermolecular and Intramolecular Electrophilic Condensation Reactions"

Albany Molecular Research, Inc.

Dr. Paul L. Wiggins, 1980

"The Synthesis of Fluorinated Terpenes and the Mechanism of Farnesyl Pyrophosphate Synthetase"

Ethyl Corporation

Professor Eugene A. Mash, Jr., 1980

"Studies with Analogs of Isopentenyl Pyrophosphate"

University of Arizona, Tucson, Department of Chemistry

Dr. Michael D. Thompson, 1981

"The Synthesis of Presqualene Analogs"

Amylin Pharmaceuticals

Dr. Timothy R. Neal, 1981

"The Synthesis of Bisubstrate Analogs of Farnesyl Pyrophosphate Synthetase"

Ricera Inc

Dr. Richard H. Griffey, 1984

"Nuclear Magnetic Resonance Spectroscopy of Nitrogen-15 Escherichia coli Transfer Ribonucleic Acids"

ISIS Corporation

Dr. Todd L. Capson, 1987

"Synthesis and Evaluation of Ammonium Analogs of Carbocationic Intermediates in Squalene Biosynthesis"

University of Utah, Department of Medicinal Chemistry

Dr. Andrew B. Woodside, 1987

"Studies of Dimethylallyl-L-Tryptophan Synthetase with Fluorinated Analogs of Dimethylallyl Diphosphate"

Owens Corning

Dr. Kay E. Stremler, 1987

"Substrate Analogs for Isoprenoid Enzymes"

Stremler International Solutions, LLC

Dr. Manfred Muehlbacher, 1987

"Active-Site-Directed Irreversible Inhibitors of Isopentenyl Diphosphate Isomerase"

Reinhalteverband Salzburg Central Laboratories

Professor Darrell R. Davis, 1988

"Nuclear Magnetic Resonance Spectroscopy of Undermodified Escherichia coli Transfer Ribonucleic Acids"

University of Utah, Department of Medicinal Chemistry

Dr. Zheng Huang, 1988

"Structure and Biosynthesis of Botryococcenes"

Merck Frosst Centre for Therapeutic Research

Professor V. Jo Davisson, 1988

"Cyclization Reactions Catalyzed by Farnesyl Diphosphate Synthetase"

Purdue University, Department of Medicinal Chemistry & Pharmacognosy

Professor William H. Gmeiner, 1988

"NMR Studies of Nucleic Acids"

Wake Forest University, School of Medicine

Dr. Douglas S. Mautz, 1990

"Phosphorothioate Substrate Analogues for Isoprenoid Enzymes"

Forest Research Institute

Dr. Carmen L. Rodriguez, 1990

"Model Studies in the Terpene Biosynthetic Pathway. Determination of the Lifetime of an Allylic Carbocation"

Arco Corp., New Process Research & Development

Dr. Donglu Zhang, 1990

"Biosynthesis of Archaebacterial Membrane Lipids. Ether Formation by a Prenyl Transfer Reaction"

Bristol Myers Squibb

Dr. John Gebler, 1990

"Mechanism of Dimethylallyl Tryptophan Synthase"

Waters Corp

Dr. Stylianos Mavromoustakos, 1991

"Model and Structural Studies of Transfer Ribonucleic Acids"

Intercollege, Cyprus, Greece

Dr. Xiangjun Lu, 1992

"Mechanism-Based Inactivation of Isopentenyl Diphosphate Isomerase"

Research Biochemicals International, a Sigma-Aldrich Company

Dr. Dale J. Christensen, 1993

"Nuclear Magnetic Resonance Spectroscopic Investigation of Peptide Structure and Enzyme Mechanism"

Cognosci

Dr. Anjun Chen, 1994

"Archaebacterial Prenyltransferases: Isolation and Characterization of Farnesyl/Geranylgeranyl Diphosphate Synthase, Geranylgeranylglyceryl Phosphate Synthase, and Their Genes"

Canova Bioconsulting

Dr. Eugene Yi, 1995

"Mechanistic Studies of Squalene Synthase Using Phosphorothioate Substrate Analogs"

Institute for Systems Biology

Dr. Pamela Cassidy, 1995

"Kinetic Mechanism and Inhibitors of Protein Farnesyltransferase"

University of Utah, Department of Medicinal Chemistry

Dr. Frederick M. Hahn, 1996

"Isopentenyl Diphosphate Isomerase: A Comparative Study"

USDA, Albany, NY

Dr. Jonathon Baker, 1998

"Isoprenoid Biosynthesis: Identification and Characterization IPP:DMAPP Isomerase From Rhodobacter, Characterization of a Eukaryotic IPP:DMAPP Isomerase and Phylogenetic Analysis of Pathway Enzymes"

ORYZON Genomics

Professor Michael Jarstfer, 1998

"Squalene Synthase: Analysis of the Enzyme Catalyzed Rearrangement of Presqualene Diphosphate and Analysis of the Squalene Synthase Peptide Sequence"

University of North Carolina, Chappel Hill, Division of Medicinal Chemistry and Natural Products

Associate Professor Owen McDougal, 1998

"Conus Peptides Investigated by Nuclear Magnetic Resonance Spectroscopic Methods"

Southern Oregon University, Department of Chemistry

Assistant. Professor Mark Pugh, 1998

"Bisubstrate Analogs and Inhibitors of Farnesyl Diphosphate Synthase"

Brigham Young University, Idaho, Department of Chemistry

Assistant Professor Hong Wang, 1998

"Dimethylallyltryptophan Synthase: Mechanism Study and Product Analysis"

University of Colorad, Denver, Anschutz Medical Campus

Assistant Professor Brian Blagg, 1999

"Intermediates in Isoprenoid Biosynthesis"

University of Kansas, Medicinal Chemistry

Assistant Professor Suzanne Fernandez, 1999

"Site-Directed Mutagenesis Studies of Farnesyl Diphosphate Synthase"

DeSales University

Assistant Professor Evette Radisky, 1999

"Elucidation of a Kinetic Mechanism for Squalene Synthase"

Mayo Clinic Cancer Center

Assistant Professor Timothy Soderberg, 2000

"Invertigation of Two Enzymes Catalyzing Transfer of Isoprenoid Groups to Nonisoprenoid Acceptors"

University of Minnesota at Morris, Department of Chemistry

Dr. Lisa Eubanks, 2002

"Investigation of Enzymes in the Isoprenoid Biosynthetic Pathways: DXP Synthase and Protein Prenyltransferases"

Scripps Research Institute, Department of Chemistry

Dr. Andrew T. Koppisch, 2002

"Enzymology of MEP Synthase"

Los Alamos National Laboratory, Bioscience Division

Dr. Susan Rivera, 2002

"Chrysanthemyl Diphosphate Synthase: Steady-State Kinetic Characterization and Mechanistic Studies of the Recombinant Non-Head-To-Tail Monoterpene Synthase from Chrysanthemum Cinerariaefolium"

CNA Corporation

Dr. Chad Testa, 2002

"A Synthetic Mevalonate Operon for Studying the Methyl Erythritol Phosphate Pathway"

Echelon Biosciences, Inc

Dr. Richard Phan, 2003

"Syntheses and Enzymatic Studies of Thioisoprenes and Bisubstrate Analogs as New Alternative Substrates/Inhibitors for the Enzyme Farnesyl Diphosphate Synthase"

CSTE-DTC-DP-WD-CT-E, Dugway Proving Grounds

Dr. James Barkley, 2003

"Type I and Type II IPP Isomerases from Methanothermobacter Thermautotrophicus, Synechocystis 6803, and Halobacterium SP. NRC-1"

SJ Quinney College of Law at the University of Utah

Professor Rita Cornish, 2003

"Genetic Identification and Characterization of Genes Involved in the 2-C-Methyl-D-Erythritol 4-Phosphate Pathway for Early Isoprenoid Biosythesis in Salmonella Typhimurium"

Ohio State University, Ohio Agricultural Research and Development Center

David Fox, 2005

"Synthesis of 1-Deoxy-D-Xylulose 5-Phosphoric Acid Analogs for Mechanistic Studies with Methylerythritol Phosphate Synthase from Escherichia Coli"

Agnew National Security

Jonathan Johnston, 2007

"Mechanistic Investigations of Types I and II Isopentenyl Diphosphate Isomerase"

University of California, San Francisco

Rochelle Hawkins-Bohaty, 2008

"A General Approach to Immobilize Proteins Regio- and Chemoselectivity to Gold Surfaces Using Protein Franesyltransferase"

American Chemical Society, Chemical and Engineering News

Nichole Heaps, 2008

"Synthesis and Evaluation of Alternative Substrates for Farnesyl Diphosphate Synthase and Isopentenyl Diphosphate Isomerase"

Sapphire Energy Inc.

Mo Chen, 2009

"Parallel Characterization of Thermophilic Isopentenyl Phosphate Kinases from Archaea"

University of Pennsylvania

 

Masters

Larry L. Marsh, 1973

"Model Studies of Non-Head-to-Tail Terpenes. Solvolysis of Chrysanthemyl Derivatives"

Top Dog Construction

Peter S. Borromeo, 1980

"Solvolysis and Product Studies of N-Methyl-4-(spiro[2.4]heptane-4-oxo)pyridinium Iodide"

Eli Lilly

Dr. John C. Gebler, 1987

"Enzymatic Synthesis of Dimethylallyl Tryptophan"

Waters Corp

Zheng Wu, 1997

"Synthesis and Evaluation of Substrate Analogs for Prenoid Enzymes"

University of Texas at Dallas

Michael Kidd, 2005

"The Cloning, Purification, and Kinetic Analysis of Archaeal Geranylgeranyl Diphosphate Synthase"

Saint Louis University

Travis Helm, 2006

"The Machanistic Characterization of a Type II Isopentenyl-dimethylallyl Diphosphate Isomerase from the Thermophilic Eubacteria Thermus Thermophilus"

Ohio State University

 

Undergraduate Researchers

M. Belt

E. Bruenger

J. Vasek

A. Weiner

M. Wolczunowicz

H. Coffman

J. Ernstsen

L. Petersen

W. Perrin

B. Patrick

M. Yan

H. Wu

D. Pori

J. Fullmer

J. Clark

B. Cromar

R. Dickson

D. Golub

R. Goodfellow

D. Heckendorn

D. James

J. Krafcik

A. Learned

S. Moesinger

D. M. Pearce

K. Rilling

B. Smith

K. Stromberg

A. K. Sugino

K. Trentleman

A. T. Le

M. Kelleher

S. Nelson

M. Zabriskie

N. Spencer

C. Roshek

C. Persons

L. Pennacchio

M. Jarstfer

A. Galbraith

S. Meyenberg

L. Alcazar-Roman

D. Weibel

J. Fullmer

M. Morrison

A. Riemer

J. Carpenter

O. Stephens

S. Phillips

A. Derdowski

R. Davis

D. Sandberg

D. Buckthal

B. Tataeko

C. Lingard

A. Sanderson

J. Morgan

N. Wang

K. Olsen