Poulter Publications - Department of Chemistry

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Ramamoorthy, G.; Mark, L. P.; Tian, B.-X.; Phan, R.M.; Perez, L. B.; Jacobson, M.P.; Poulter, C. D. “Synthesis and enzymatic studies of bisubstrate analogues for fanesyl diphosphate synthase” J. Org. Chem, 2015, 80, 3902-3913.
Chow, J.-Y.; Tian, B.-X.; Ramamoorthy, G.; Hillerich, B. S.; Seidel, R. D.; Almo, S. C.; Jacobson, M. P.; Poulter, C. D. “Computational-guided discovery and characterization of a sesquiterpene synthase from Streptomyces clavuligerus” Proc. Nat. Acad. Sci. USA, 2015, 112, 5661-5666.
Pan, J.-J.; Solbiati, J.O.; Ramamoorthy, G.; Hillerich, B. S.; Seidel, R. D.; Cronan, J. E.; Almo, S. C.; Poulter, C. D. “Biosynthesis of Squalene from Farnesyl Diphosphate in Bacteria: Three Steps Catalyzed by Three Enzymes” ACS Cent. Sci., 2015, 1, 77-82.
Tian, B.; Wallrapp, F.H.; Holiday, G.L.; Chow, J.-Y.; Babbitt, P.C.; Poulter, C.D.; Jacobson, M.P. “Predicting the Functions and Specificity of Triterpenoid Synthases: A Mechanism-Based Multi-Intermediate Docking Approach” PLoS Computational Biology, 2014, 10, e1003874.
Krasutsky, S.G.; Urbansky, M.; Davis, C.E.; Lherbet, C.; Coates, R.M.; Poulter, C.D. “Synthesis of Methylerythritol Phosphate Analogues and their Evaluation as Alternate Substrates for IspDF and IspE from Agrobacterium tumefaciens” J. Org. Chem., 2014, 79, 9170-9178.
de Ruyck, J.; Janczak, M. W.; Neti, S. S.; Rothman, S. C.; Schubert, H. L; Cornish, R. M.; Matagne, A.; Wouters, J.; Poulter, C. D. “Determination of Kinetics and the Crystal Structure of a Novel Type 2 Isopentenyl Diphosphate: Dimethylallyl Diphosphate Isomerase from Streptococcus pneumonia” ChemBioChem, 2014, 15, 1452-1458.
Choi, S.-R..; Seo, J.-S.; Bohaty, R. F. H.; Poulter, C.D. “Regio- and Chemoselective Immobilization of Proteins on Gold Surfaces” Bioconjugate Chem. 2014, 25, 269-275.
de Ruyck, J.; Schubert, H.L.; Janczak, M.W.; Poulter, C.D. “Tetartohedral twinning in IDI-2 from Thermus thermophilus: crystallization under anaerobic conditions” Acta Cryst, 2014, F70, 347-349.
Rudolf, J. D.; Poulter, C. D. “Tyrosine O-Prenyltransferase SirD Catalyzes S-, C-, and N-Prenylations on Tyrosine and Tryptophan Derivatives” ACS Chemical Biology2013, 8, 2707-2714.
Pan, J.-J.; Ramamoorthy, G.; Poulter, C. D. “Dependence of the product chain-length on detergents for long-chain E-polyprenyl diphosphate synthases” Biochemistry2013, 52, 5002-5008.
Seo, J.-S.; Lee, S.; Poulter, C. D. “Regioselective Covalent Immobilization of Recombinant Antibody-Binding Proteins A, G, and L for Construction of Antibody Arrays” J. Am. Chem. Soc.2013, 135, 8973-8980.
Wallrapp, F. H.; Pan, J.-J.; Ramamoorthy, G.; Almonacid, D. E.; Hillerich, B. S.; Seidel, R.; Patskovsky, Y.; Babbitt, P. C.; Almo, S. C.; Jacobson, M. P.; Poulter, C. D. “Prediction of function for the polyprenyl transferase subgroup in the isoprenoid synthase superfamily” Proc. Natl. Acad. Sci.2013, 110, E1196-E1202.
Viswanathan, R.; Labadie, G.; Poulter, C. D. “Regioselective Covalent Immobilization of Catalytically Active Glutathione S-Transferase on Glass Slides” Bioconjugate Chem.2013, 24, 571-577.
Janthawornpong, K.; Krasutsky, S.; Chaignon, P.; Rohmer, M.; Poulter, C. D.; Seemann, M. “Inhibition of IspH, a [4Fe−4S]2+ Enzyme Involved in the Biosynthesis of Isoprenoids via the Methylerythritol Phosphate Pathway” J. Am. Chem. Soc.2013, 135, 1816-1822.
Rudolf, J. D.; Wang, H.; Poulter, C. D. “Multisite Prenylation of 4-Substituted Tryptophans by Dimethylallyltryptophan Synthase” J. Am. Chem. Soc.2013, 135, 1895-1902.
Bellesia, F.; Choi, S.-R.; Felluga, F.; Fiscaletti, G.; Ghelfi, F.; Menziani, M. C.; Parsons, A. F.; Poulter, C. D.; Roncaglia, F.; Sabbatini, M.; Spinelli, D. “Novel route to chaetomellic acid A and analogues: Serendipitous discovery of a more competent FTase inhibitor.” Bioorg. Med. Chem. 2013, 21, 348-358.
Mabanglo, M. F.; Pan, J.-J.; Shakya, B.; Poulter, C. D. “Mutagenesis of isopentenyl phosphate kinase to enhance geranyl phosphate kinase activity” ACS Chem. Biol.2012, 7, 124-1246.
Poulter, C.D.;Labadie, G.R.; Gauchet, C; Bohaty, R.F.H. “Immobilized proteins and methods and uses thereof” U.S. Patent 8,188,241 B2, May 29, 2012.
Mabanglo, M.F.; Serohijos, A.W.R.; Poulter, C.D. “The Streptomyces-Produced Antibiotic Fosfomycin is a Promiscuous Substrate for Archaeal Isopentenyl Phosphate Kinase” Biochemistry, 2012, 51, 917-925.
Heaps, N.A.; Poulter, C.D. “Type 2 Isopentenyl Diphosphate Isomerase: Evidence for a Stepwise Mechanism” J. Am. Chem. Soc., 2011, 133, 19017-19019.
Nagai, T.; Unno, H.; Janczak, M.W.; Yoshimura, T.; Poulter, C.D.; Hemmi, H. “Covalent Modification of Reduced Flavin Mononucleotide in Type 2 Isopentenyl Diphosphate Isomerase by Active-Site-Directed Inhibitions” Proc. Natl. Acad. Sci. USA, 2011, 108, 20461-20466.
Gerlt, J.A.; Allen, K.A.; Almo, S.C.; Armstrong, R.N.; Babbitt, P.C.; Cronan, J.E.; Dunaway-Mariano, D.; Imker, H.; Jacobson, M.P.; Minor, W.; Poulter, C.D.; Raushel, F.M.; Sali, A.; Shoichet, B.K.; Sweedler, J.V. “The Enzyme Function Initiative” Biochemistry, 2011, 50, 9950-9962.
Ahrens-Botzong, A.; Janthawornpong, K.; Wolny, J.A.; Tambou, E. N.; Rohmer, M.; Krasutsky, S.; Poulter, C. D.; Schunemann, V.; Seemann, M. “Biosynthesis of Isoprene Units: Mossbauer Spectroscopy of Substrate and Inhibitor Binding to the [4Fe-4S] Cluster of the LytB/IspH Enzyme” Angew. Chem. Int. Ed., 2011, 50, 11976-11979.
de Ruyck, J.; Wouters, J.; Poulter, C. D. “Inhibition studies on Enzymes Involved in Isoprenoid Biosynthesis: Focus on Two Potential Drug Targets: DXR and IDI-2 Enzymes” Curr. Enz. Inhib. 2011, 7, 79-95.
Heaps, N. A.; Poulter, C. D. “Synthesis and Evaluation of Chlorinated Substrate Analogues for Farnesyl Diphosphate Synthase” J. Org. Chem2011, 76, 1838-1843.
Poulter, C.D.; Hahn, F.; Cornish, R.; Testa, C. “Antibacterial and Herbicidal Compounds and System for Screening the Same” U.S. Patent 7,736,881, June 15, 2010.
Sharma, N.K.; Pan, J.J; Poulter, C. D. “Type II Isopentenyl Diphosphate Isomerase: Probing the Mechanism with Alkyne/Allene Diphosphate Substrate Analogues” Biochemistry2010, 49, 6228-6233.
Koohang, A.; Bailey, J.L.; Coates, R.M.; Erickson, H.L.; Owen, D.; Poulter, C.D. “Enantioselective Inhibition of Squalene Synthase by Azridine Analogues of Presqualane Diphosphate” J. Org. Chem.2010, 75, 4769-4777.
Mabanglo, M.F.; Schubert, H.L.; Chen, M.; Hill, C.P.; Poulter, C.D. “X-ray Structures of Isopentenyl Phosphate Kinase” ACS Chem. Biol.2010, 5, 317-327.
Chen, M.; Poulter, C.D. “Characterization of Thermophilic Archaeal Isopentenyl Phosphate Kinases”, Biochemistry2010, 49, 207-217.
Pan, J.-J.; Bugni, T.S.; Poulter, C.D. “Recombinant Squalene Synthase. Synthesis of Cyclopentyl Non-Head-to-Tail Triterpenes” J. Org. Chem.2009, 74, 7562-7565.
Poulter, C.D.; “Bioorganic Chemistry. A Natural Reunion of the Physical and Life Sciences” J. Org. Chem.2009, 74, 2631-2645.
de Ruyck, J.; Pouyez, J.; Rothman, S.C.; Poulter, C.D.; Wouters, J. “Crystal Structure of Type 2 Isopentenyl Diphosphate Isomerase from Thermus thermophilus in Complex with Inorganic Pyrophosphate” Biochemistry2008, 47, 9051-9053.
Lee, S.; Poulter, C.D. “Cloning, Solubilization, and Characterization of Squalene Synthase from Thermosynechococcus elongates BP-1” J. Bacteriol.2008, 190, 3808-3816.
Rothman, S.C.; Johnston, J.B.; Lee, S.; Walker, J.R.; Poulter, C.D. “Type II Isopentenyl Diphosphate Isomerase: Irreversible Inactivation by Covalent Modification of Flavin” J. Am. Chem. Soc., 2008, 130, 4906-4913.
McDougal, O. M.; Turner, M.W.; Ormond, A.J.; Poulter, C.D. “Three-Dimensional Structure of Conotoxin tx3a: An m-1 Branch Peptide of the M-Superfamily” Biochemistry, 2008, 47, 2826-2832.
Thulasiram, H.V.; Erickson, H.K.; Poulter, C.D. “A Common Mechanism for Branching, Cyclopropanation, and Cyclobutanation Reactions in the Isoprenoid Biosynthetic Pathway” J. Am. Chem. Soc., 2008, 130, 1966-1971.
Walker, J.R.; Rothman, S.C.; Poulter, C.D. “Synthesis and Evaluation of Substrate Analogues as Mechanism Based Inhibitors of Type II Isopentenyl Diphosphate Isomerase” J. Org. Chem., 2008, 73 (2), 726-729.
Labadie, G.R.; Viswanathan, R.; Poulter, C.D. “Farnesyl Diphosphate Analogues with omega-Bioorthogonal Azide and Alkyne Functional Groups for PFTase-Catalyzed Ligation Reactions” J. Org. Chem., 2007, 72, 9291-9297.
Johnston, J.B.; Walker, J.R.; Rothman, S.C.; Poulter, C.D. “Type-2 Isopentenyl Diphosphate Isomerase. Mechanistic Studies with Cyclopropyl and Epoxy Analogs” J. Am. Chem. Soc. 2007, 129, 7740-7741.
Thulasiram, H.V.; Erickson, H.K.; Poulter, C.D. “Chimeras of Two Isoprenoid Synthases Catalyze all Four Coupling Reactions in Isoprenoid Biosynthesis” Science2007,316, 73-76.
Rothman, S.C.; Helm, T.R.; Poulter, C.D. “Kinetic and Spectroscopic Characterization of Type II Isopentenyl Diphosphate Isomerase from Thermus thermophilus: Evidence for Formation of Substrate-induced Flavin Species” Biochemistry, 2007, 46, 5437-5445.
Thulasiram, H.V.; Poulter, C.D. “Farnesyl Diphosphate Synthase: The Art of Compromise between Substrate Selectivity and Stereoselectivity” J. Am. Chem. Soc.2006, 128, 15819-15823.
Lee, S.; Poulter, C.D.“Escherichia coli Type I Isopentenyl Diphosphate Isomerase: Structural and Catalytic Roles for Divalent Metals”J. Am. Chem. Soc.2006, 128, 11545-11550.
Gauchet, C.; Labadie, G.R.; Poulter, C.D. “Regio- and Chemoselective Covalent Immobilization of Proteins through Unnatural Amino Acids” J. Am. Chem. Soc.2006, 128, 9274-9275.
Thulasiram, H.V.; Phan, R.M.; Rivera, S.B.; Poulter, C.D. “Synthesis of Deuterium Labeled Derivatives of Dimethylallyl Diphosphate” J. Org. Chem., 2006, 71, 1739-1741.
Lherbet, C.; Pojer, F.; Richard, S.B.; Noel, J.P.; Poulter, C.D. “Absence of Substrate Channeling between Active Sites in the Agrobacterium tumefaciens IspDF and IspE Enzymes of the Methyl Erythritol Phosphate Pathway” Biochemistry, 2006, 45, 3548-3553.
Cornish, R.M.; Roth, J.R.; Poulter, C.D. “Lethal mutations in the isoprenoid pathway of Salmonella enterica”J. Bacteriol., 2006, 188, 1444-1450.
Testa, C.A.; Lherbet, C.; Pojer, F.; Noel, J.P; Poulter, C.D. “Cloning and Expression of IspDF from Mesorhizobium loti. Characterization of a Bifunctional Protein that Catalyzes Non-Consecutive Steps in the Methylerythritol Phosphate Pathway” Biochem. Biophys. Acta, 2006, 1764, 85-96.
Poulter, C.D. “Farnesyl Diphosphate Synthase. A Paradigm for Understanding Structure and Function Relationships in E-Polyprenyl Diphosphate Synthases” Phytochem. Reviews, 2006, 5, 17-26.
Wu, Z.; Wouters, J.; Poulter, C.D. “Isopentenyl Diphosphate Isomerase. Mechanism-Based Inhibition by Diene Analogues of Isopentenyl Diphosphate and Dimethylallyl Diphosphate” J. Am. Chem. Soc., 2005, 127, 17433-17438.
Walker, J.R.; Poulter, C.D. “Synthesis and Evaluation of 1-Deoxy-D-xylulose 5-Phosphate Analogs as Chelation Based Inhibitors of Methylerythritol Phosphate Synthase” J. Org. Chem., 2005, 70, 9955-9959.
de Ruyck, J.; Rothman, S.C.; Poulter, C.D.; Wouters, J. “Structure of Thermus thermophilus type 2 isopentenyl diphosphates isomerase inferred from crystallography and molecular dynamics” Biochem. and Biophys. Res. Comm., 2005,338, 1515–1518.
Fox, D.T.; Poulter, C.D. “Mechanistic Studies with 2C-Methyl-D-erythritol 4-Phosphate Synthase from Escherichia coli” Biochemistry, 2005, 44, 8360-8368.
Fox, D.T.; Poulter, C.D. “Synthesis and Evaluation of 1-Deoxy-D-xylulose 5-Phosphoric Acid Analogs as Alternate Substrates for Methylerythritol Phosphate Synthase” J. Org. Chem., 2005, 70, 1978-1985.
Barkley, S.J.; Desai, S.V.; Poulter, C.D. “Proton Exchange in Type II Isopentenyl Diphosphate Isomerase” Org. Lett., 2004, 6, 5019-5021.
Barkley, S.J.; Desai, S.B.; Poulter, C.D. “Type II Isopentenyl Diphosphate Isomerase from Synechosycsis sp. Strain PCC 6803” J. Bacteriol., 2004, 186, 81156-8158.
Jitkova, J.; Carrigan, C.N.; Poulter, C.D.; Krylov, S.N. “Monitoring the Three Enzymatic Activities Involved in Posttranslational Modifications of Ras Proteins” Anal. Chim. Acta, 2004. 521, 1-7.
McDougal, O.M.; Poulter, C.D. “Three-Dimensional Structure of the Mini-M Conotoxin mr3a” Biochemistry, 2004, 43, 425-429.
Wouters, J.; Oudjama, Y.; Stalon, V.; Droogmans, L.; Poulter, C.D. “Crystal Structure of the C67A Mutant of Isopentenyl Diphosphate Isomerase Complexed with a Mechanism-Based Irreversible Inhibitor” Proteins, 2004, 54, 216-221.
Scholte, A.; Eubanks, L.; Poulter, C.D.; Vederas, J. “Synthesis and Biological Activity of Isopentenyl Diphosphate Analogs” Bioorg. Med. Chem, 2004, 12, 763-770.
Testa, C.A.; Cornish, R.M.; Poulter, C.D. “ The Sorbitol Phosphotransferase System is Responsible for the Transport of 2-C-Methyl D-Erythriotol into Salmonella enterica terovar Typhimurium” J. Bacteriology, 2004, 186, 473-480.
Barkley, S.J.; Cornish, R.M.; Poulter, C.D. “Identification of an Archaeal Type II Isopentenyl Diphosphate Isomerase in Methanothermobacter thermautotrophicus” J. Bacteriology, 2004, 186, 1811-1817.
Carrigan, C.N.; Poulter, C.D. “Zinc is an Essential Cofactor for Type I Isopentenyl Diphosphate: Dimethylallyl Diphosphate Isomerase” J. Am. Chem. Soc., 2003, 30, 9008-9009.
Erickson, H.; Poulter, C.D. “Chrysanthemyl Diphosphate Synthase. The Relationship among Chain Elongation, Branching and Cyclopropanation Reactions in the Isoprenoid Biosynthetic Pathway” J. Am. Chem. Soc., 2003, 23, 6885-6888.
Hemmerlin, A.; Rivera, S.B.; Erickson, H.; Poulter, C.D. “Enzymes Encoded by the Farnesyl Diphosphate Synthase Gene Family in the Big Sagebrush Artemisia tridentata spp. spiciformis” J. Biol. Chem., 2003, 34, 32132-32140.
Eubanks, L.M.; Poulter, C.D. “Rhodobacter capsulatus 1-Deoxy-D-xylulose 5-Phosphate Synthase: Steady-State Kinetics and Substrate Binding” Biochemistry, 2003, 42, 1140-1149.
Wouters, J.; Oudjama, Y.; Barkley, S.J.; Tricot, C.; Stalon, V.; Droogmans, L.; Poulter, C.D. “Catalytic Mechanism of E. coli Isopentenyl Diphosphate Isomerase Involves Cys67, Glu116 and Tyr104 as Suggested by Crystal Structures of Complexes with Transition State Analogues and Irreversible Inhibitors” J. Biol. Chem., 2003, 278, 11903-11908.
Iwata-Reuyl, D.; Math, S.K.; Poulter, C.D. “Bacterial Phytoene Synthase: Molecular Cloning, Over-Expression and Characterization of Erwinia herbicola Phytoene Synthase” Biochemistry, 2003, 42, 3359-3365.
Berezovski, M.; Li, W.-P.; Poulter, C.D.; Krylov, S. N. “Measuring the Activity of Farnesyltransferase by Capillary Electrophoresis with Laser-Induced Fluorescence Detection” Electrophoresis, 2002, 23, 3398-3403.
Harris, C.M.; Derdowski, A.M.; Poulter, C.D. “Modulation of the Zn(II) Center in Protein Farnesyltransferase by Mutagenesis of the Zn(II) Ligands”, Biochemistry,2002, 41, 10554-10562.
Koppish, A.T.; Poulter, C.D. “Synthesis of 4-Diphosphocytidyl-2-C-methyl-D-erythritol and 2-C-Methyl-D-erythritol 4-Phosphate” J. Org. Chem., 2002, 67, 5416-5418.
Blagg, B.S.J.; Jarstfer, M.B.; Rogers, D.H., Poulter, C.D. “Recombinant Squalene Synthase. A Mechanism for the Rearrangement of Presqualene Diphosphate to Squalene” J. Am. Chem. Soc.2002, 124, 8846-8853.
Jarsfter, M.B.; Zhang, D.L.; Poulter, C.D. “Recombinant Squalene Synthase. Synthesis of Non-Head-to-Tail Isoprenoids in the Absence of NADPH” J. Am. Chem. Soc.2002, 124, 8834-8845.
Fox, D.T.; Poulter, C.D. “Synthesis of (E)-4-Hydroxydimethylallyl Diphosphate. An Intermediate in the Methyl Erythritol Phosphate Branch of the Isoprenoid Pathway” J. Org. Chem., 2002, 67, 5009-5010.
Koppish, A.T.; Fox, D.T.; Blagg, B.S.J.; Poulter C.D. “E. coli MEP Synthase: Steady-State Kinetic Analysis and Substrate Binding” Biochemistry2002, 41, 236-243.
Mu, Y.Q.; Eubanks, L.M.; Poulter, C.D.; Gibbs, R.A. “Coupling of Isoprenoid Triflates with Organoboron Nucleophiles: Synthesis and Biological Evaluation of Geranylgeranyl Diphosphate Analogs” Bioorg. Med. Chem.2002, 10, 1207-1219.
Soderberg, T.; Chen, A.; Poulter, C.D. “Geranylgeranylglyceryl Phosphate Synthase. Characterization of the Recombinant Enzyme from Methanobacterium thermoautotrophicum”, Biochemistry,2001, 40,14847-14854.
Phan, R.M.; Poulter, C.D. “Synthesis of (S)-Isoprenoid Thiodiphosphates as Substrates and Inhibitors”, J. Org. Chem.2001, 66, 6705-6710.
Rivera, S.B.; Swedlund, B.D.; King, G.J.; Bell, R.N.; Hussey, Jr., C.E.; Shattuck-Eidens, D.M.; Wrobel, W.M.; Peiser, G.D.; Poulter, C.D. “Chrysanthemyl Diphosphate Synthase: Isolation of the Gene and Characterization of the Recombinant Non-Head-to-Tail Monoterpene Synthase from Chrysanthemum cinerariaefolium”, Proc. Natl. Acad. Sci. US,2001, 98, 4373-4378.
Soderberg, T.; Poulter, C.D. “Escherichia coli Dimethylallyl Diphosphate:tRNA Dimethylallyltransferase: Site-Directed Mutagenesis of Highly conserved Residues”, Biochemistry2001,40, 1734-1740.
Dolence, E.K.; Dolence, J.M.; Poulter, C.D. “Solid-Phase Synthesis of a Radiolabeled, Biotinylated, and Farnesylated Ca₁a₂X Peptide Substrates for Ras- and a-Mating Factor Converting Enzyme”, Bioconjugate Chem.2001, 12, 35-43.
Dunford, J.E.; Coxon, F.P.; Luckman, S.P.; Thompson, K.; Hahn, F.M.; Poulter, C.D.; Rogers, M.J. “Identification of FPP Synthase, the Molecular Target of Nitrogen-Containing Bisphosphonates, Using a Cell-Free Protein Prenyl Assay”, J. Pharm. Exper. Therapeutics2001, 296, 235-242.
Hahn, F.M.; Eubanks, L.M.; Blagg, B.S.J.; Testa, C.; Baker, J.A..; Poulter, C.D. “1-Deoxyxylulose-5-Phosphate Synthase: The Gene Product of both ORF 2816 and ORF 2895 in Rhodobacter capsulatus”, J. Bacteriology2001, 183, 1-11.
Fernandez, S.M.; Kellogg, B.A.; Poulter, C.D. “Farnesyl Diphosphate Synthase. Altering the Catalytic Site to Select for Geranyl Diphosphate Activity”, Biochemistry2000, 39, 15316-17.
Dolence, E.K.; Dolence, J.M.; Poulter, C.D. “Solid-Phase Synthesis of a Farnesylated CaaX Peptide Library: Inhibitors of the Ras CaaX Endoprotease”, J. Comb. Chem, 20002, 522-536.
Phan, R.M.; Poulter, C.D. “Synthesis of Geranyl S-thiolodiphosphate. A New Alternate Substrate/Inhibitor for Prenyltransferases”, Org Lett2000, 2, 2287-2289.
Moore, J.A.; Mathis, J.R.; Poulter, C.D. “Escherichia coli Dimethylallyl Diphosphate: tRNA Dimethylallyltransferase: Presteady State Kinetic Studies,” Biochim et Biophys Acta 2000, 1479, 166-174.
Trueblood, C.E.; Boyartchuk, V.L.; Picologlou, E.; Rozema, D.; Poulter, C.D.; Rine, J. “The CaaX Proteases, Afc1p and Rce1p, Have Overlapping but Distinct Substrate Specificities”, Molec. Cell. Biol.2000, 20, 4381-4392.
Soderberg, T.; Poulter, C.D. “Escherichia coli Dimethylallyl Diphosphate:tRNA Dimethylallyltransferase: Essential Elements for Recognition of tRNA Substrates Within the Anticodon Stem-Loop”, Biochemistry, 2000, 39, 6546-6553.
Harris, C.M.; Poulter, C.D. “Recent Studies of the Mechanism of Protein Prenylation”, Nat. Prod. Rept. 2000, 17, 131-214.
Dolence, J.M.; Steward, L.E.; Dolence, E.K.; Wong, D.H. Poulter, C.D. “Overproduction of the Yeast CaaX Prenyl Protease Rce1p in Saccharomyces cerevisiae and Its Initial Biochemical Characterization”, Biochemistry2000, 39, 4096-4104.
Radisky, E.S.; Poulter, C.D. "Squalene Synthase: Steady State, Pre-Steady State, and Isotope Trapping Studies", Biochemistry2000, 39, 1748-1760.
Koppisch, A.T.; Blagg, B.S.J.; Poulter, C.D. “Synthesis of 2-C-Methyl-D-erythritol-4-phosphate: The First Pathway Specific Intermediate in the Methylerythritol Phosphate Route to Isoprenoids”, Org Lett2000, 2, 215-217.
Rozema, D.B.; Poulter, C.D. "Yeast protein Farnesyltransferase. pK_as of Peptide Substrates Bound as Zinc Thiolates" Biochemistry1999, 38, 13138-13146.
Leyes, A.E.; Baker, J.A.; Poulter, C.D. "Biosynthesis of Isoprenoids in E. coli: Stereochemistry of the Reaction Catalyzed by Farnesyl Diphosphate Synthase", Org Lett1999, 1, 1071-1073.
Leyes, A.E.; Poulter, C.D. "Synthesis of (R)-[2-²H]isopentenyl Diphosphate and Determination of Its Enantiopurity by ²H NMR Spectroscopy in a Lyotropic Medium", Org. Lett.1999, 1, 1067-1070.
Rozema, D.B.; Phillips, S.T.; Poulter, C.D. " Yeast Protein Farnesyltransferase. Binding of S-Alkyl Peptides and Related Analogs", Org. Lett.1999, 1, 815-817.
Wu, Z.; Demma, M.; Strickland, C.L.; Radisky, E.S.; Poulter, C.D.; Le, H.V.; Windsor, W.T. "Farnesyl Protein Transferase: Identification of K164a and Y300b as Catalytic Residues by Mutagenesis and Kinetic Studies", Biochemistry1999, 38, 11239-11249.
Hahn, F.M.; Hurlburt, A.P.; Poulter, C.D. “Escherichia coli Open Reading Frame 6961 is idi, a Non-Essential Gene Encoding Isopentenyl Diphosphate Isomerase,” J. Bacteriology1999, 181, 4499-4504.
Leyes, A.E.; Baker, J.A.; Hahn, F.M.; Poulter, C.D. “Biosynthesis of Isoprenoids in Escherichia coli: Stereochemistry of the Reaction Catalyzed by Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase,” Chem. Comm.1999, 717-718.
Blagg, B.S.J.; Poulter, C.D. “Synthesis of 1-Deoxy-D-xylulose and 1-Deoxy-D-xylulose-5-phosphate,” J. Org. Chem.1999, 64, 1508-1511.
Koohang, A.; Coates, R.M.; Owen, D.; Poulter, C.D. “Synthesis and Evaluation of Aziridine Analogs of Presqualene Diphosphate as Squalene Synthase Inhibitors,” J. Org. Chem. 1999, 64, 6-7.
Dolence, J.M.; Poulter, C.D. “Electrophilic Alkylations, Isomerizations, and Rearrangements.” In Comprehensive Natural Products Chemistry; Meth-Cohn, O., Ed.; Elsevier: Oxford, 1998,Vol. 5, pp. 18473-18500.
Poulter, D.; Goldenberg, D. “Structure: Organic biological molecules.” In Principles of Chemistry in Biology; Theil, E.C., Ed.; Am. Chem. Soc.: Washington, DC, 1998, pp. 1-49.
Kellogg, B.; Poulter, C.D. "Chain Elongation in the Isoprenoid Biosynthetic Pathway." Curr. Opin. Chem. Biol.1997, 1, 570-578.
Campbell, M.; Hahn, F.M.; Poulter, C.D.; Leustek, T. "Analysis of the Isopentenyl Diphosphate Isomerase Gene Family from Arabidopsis thaliana." Plant Molec. Biol.1997, 36, 323-328.
Sacchettini, J.C.; Poulter, C.D. "Creating Isoprenoid Diversity." Science 1997, 277, 1788.
Dolence, J.M.; Rozema, D.M.; Poulter, C.D. "Yeast Protein Farnesyltransferase. Site-Directed Mutagenesis of Conserved Residues in the b-Subunit." Biochemistry 1997, 36, 9246-9252.
Mathis, J.R.; Back, K.; Starks, C.; Noel, J.; Poulter, C.D.; Chappell, J. "A Pre-Steady State Study of Recombinant Sesquiterpene Cyclases." Biochemistry 1997, 36, 8340-8348.
Mathis, J.R.; Poulter, C.D. "Yeast Protein Farnesyltransferase. A Presteady-State Kinetic Analysis." Biochemistry 1997, 36, 6367-6376.
Stirtan, W.G.; Poulter, C.D. "Yeast protein Geranylgeranyltransferase Type-I: Steady-state Kinetics and Substrate Binding." Biochemistry 1997, 36, 4552-4557.
Moore, J.A.; Poulter, C.D. "Escherichia coli Dimethylallyl Diphosphate: tRNA Dimethylallyltransferase." Biochemistry 1997, 36, 604-614.
Jarstfer, M.B.; Blagg, B.S.J.; Rogers, D.H.; Poulter, C.D. "Biosynthesis of Squalene. Evidence for a Tertiary Cyclopropylcarbinyl Cationic Intermediate in the Rearrangement of Presqualene Diphosphate to Squalene." J. Amer. Chem. Soc. 1996, 118, 13089-13090.
Tarshis, L.C.; Proteau, P.J.; Kellogg, B.A.; Sacchettini, J.C.; Poulter, C.D. "Regulation of Product Chain Length by Isoprenyl Diphosphate Synthases." Proc. Natl. Acad. Sci. USA 1996, 93, 15018-15023.
Mu, Y.-Q.; Gibbs, R.A.; Eubanks, L.M.; Poulter, C.D. "Cuprate-Mediated Synthesis and Biological Evaluation of Cyclopropyl and tert-Butyl Farnesyl Diphosphate Analogs." J. Org. Chem. 1996, 61, 8010-8015.
Poulter, C.D. "Mechanistic Studies of the Prenyl Transfer Reaction with Fluorinated Substrate Analogs." In Biomedical Frontiers of Fluorine Chemistry; I. Ojima, J.R. McCarthy, J.T. Welch, Eds.; ACS Symposium Series 639, 1996, 158-168.
Cassidy, P.B.; Poulter, C.D. "Transition State Analogs for Protein Farnesyltransferase." J. Am. Chem. Soc. 1996, 118, 8761-8762.
Ratemi, E.S.; Dolence, J.M.; Poulter, C.D.; Vederas, J.C. "Synthesis of Protein Farnesyltransferase and Protein Geranylgeranyl-transferase Inhibitors: Rapid Access to Chaetomellic Acid A and Its Analogues." J. Org. Chem. 1996, 61, 6296-6301.
Witter, D.J.; Poulter, C.D. "Yeast Geranylgeranyltransferase Type-II: Steady State Kinetic Studies of the Recombinant Enzyme." Biochemistry 1996, 35, 10454-10463.
Hahn, F.M.; Xuan, J.W.; Chambers, A.F.; Poulter, C.D. "Human Isopentenyl Diphosphate:Dimethylallyl Diphosphate Isomerase: Overproduction, Purification and Characterization." Arch. Biochem. Biophys. 1996, 332, 30-34.
Biller, S.A.; Neuenschwander, K.; Ponpipom, M.M.; Poulter, C.D. "Squalene Synthase Inhibitors." Current Pharm. Design 1996, 2, 1-40.
Moore, J.A.; Chen, A.; Mujing, Y.; Hurlburt, A.P.; Poulter, C.D. "Identification of the gltX Gene Encoding Glutamyl-tRNA Synthetase from Methanobacterium thermoautotrophicum." Biochim. Biophys. Acta 1996, 1305, 113-116.
Hahn, F.M.; Baker, J.A.; Poulter, C.D. "Open Reading Frame 176 in the Photosynthesis Gene Cluster of Rhodobacter capsulatus Encodes idi, a Gene for Isopentenyl Diphosphate Isomerase." J. Bacteriol. 1996, 178, 619-624.
Dolence, J.M.; Poulter, C.D. "Synthesis of Analogs of Farnesyl Diphosphate." Tetrahedron Symposium-in-Print, 1996, 52, 119-130.
Anderson-Altmann, K.L.; Phung, C.G.; Mavromoustakos, S.; Zheng, Z.; Facelli, J.C.; Poulter, C.D.; Grant, D.M. "The ¹⁵N Chemical Shift Tensors of Uracil Determined from ¹⁵N Powder Pattern and ¹⁵N-¹³C Dipolar NMR Spectroscopy." J. Phys. Chem. 1995, 99, 10454-10458.
Dolence, J.M.; Cassidy, P.B.; Mathis, J.R.; Poulter, C.D. "Yeast Protein Farnesyl-transferase: Steady-State Kinetic Studies of Substrate Binding." Biochemistry 1995, 34, 16687-16694.
Tsai, H.-F.; Wang, H.; Gebler, J.C.; Poulter, C.D.; Schardl, C.L. "The Claviceps purpurea Gene Encoding Dimethylallyltryptophan Synthase, the Committed Step for Ergot Alkaloid Biosynthesis." Biochem. Biophys. Res. Comm. 1995, 216, 119-125.
Gibbs, R.A.; Krishna, U.; Dolence, J.; Poulter, C.D. "A Stereoselective Palladium/Copper-Catalyzed Route to Isoprenoids. Synthesis and Biological Evaluation of 13-Methylidenefarnesyl Diphosphate." J. Org. Chem. 1995, 60, 7821-7829.
Humpf, H.-U.; Berova, N.; Nakanishi, K.; Jarstfer, M.B.; Poulter, C.D. "Allylic and Homoallylic CD Exciton Chirality: A Sensitive Method for Determining the Absolute Stereochemistry of Natural Products." J. Org. Chem. 1995, 60, 3539-3542.
Jiang, Y.; Proteau, P.; Poulter, C.D.; Ferro-Novick, S. "BTS1 Encodes a Geranylgeranyl Diphosphate Synthase Saccharomyces cerevisiae." J. Biol. Chem. 1995, 270, 21793-21799.
Doyle, M.P; Protopopova, M.N.; Poulter, C.D.; Rogers, D.H. "Macrocyclic Lactones from Dirhodium(II) Catalyzed Intramolecular Cyclopropanation and Carbon-Hydrogen Insertion." J. Am. Chem. Soc. 1995, 117, 7281-7282.
Stirtan, W.G.; Poulter, C.D. "Yeast Protein Geranylgeranyltransferase Type-I: Overproduction, Purification and Characterization." Arch. Biochem. Biophys. 1995, 321, 182-190.
Dolence, J.M.; Poulter, C.D. "A Mechanism for Posttranslational Modification of Proteins by Yeast Protein Farnesyl Transferase." Proc. Natl. Acad. Sci. 1995, 92, 5008-5011.
Hahn, F.M.; Poulter, C.D. "Isolation of Schizosaccharomyces pombe Isopentenyl Diphosphate Isomerase cDNA Clones by Complementation and Synthesis of the Enzymes in E. coli." J. Biol. Chem. 1995, 270, 11298-11303.
Rogers, D.H.; Yi, E.C.; Poulter, C.D. "An Enantioselective Synthesis of (+)-Presqualene Diphosphate.” J. Org. Chem. 1995, 60, 941-945.
Zhang, D.; Poulter, C.D. "Biosynthesis of Non-Head-to-Tail Isoprenoids. Syntheses of 1'-1 and 1'-3 Structures by Recombinant Yeast Squalene Synthase." J. Am. Chem. Soc. 1995, 117, 1641-1642.
Cassidy, P.B.; Dolence, J.M.; Poulter, C.D. "Continuous Fluorescence Assay for Protein Prenyltransferases." In Methods in Enzymology; P.J. Casey, J.E. Buss, Eds.; Academic Press: San Diego, 1995, Vol. 250, pp. 30-43.
Chen, A.; Kroon, P.; Poulter, C.D. "Isoprenyl Diphosphate Synthases: Protein Sequence Comparisons, A Phylogenetic Tree, and Predictions of Secondary Structure." Protein Sci. 1994, 3, 600-607.
Christensen, D.J.; Poulter, C.D. "Enzymatic Synthesis of Isotopically Labeled Isoprenoid Diphosphates." Bioorg. Med. Chem. 1994, 2, 631-637.
Tarshis, L.C.; Yan, M.; Poulter, C.D.; Sacchettini, J.C. "Crystal Structure of Recombinant Farnesyl Diphosphate Synthase at 2.6 Å." Biochemistry 1994, 33, 10871-10877.
Poulter, C.D.; Dolence, J.M.; Bond, P.D. "Protein Farnesyltransferase: A Mechanism of Action." J. Protein Chem. 1994, 13, 488-489.
Chen, A.; Poulter, C.D. "Isolation and Characterization of idsA. The Gene for the Short Chain Isoprenyl Diphosphate Synthase from Methanobacterium thermoautotrophicum." Arch. Biochem. Biophys. 1994, 314, 399-404.
Street, I.P.; Coffman, H.R.; Baker, J.A.; Poulter, C.D. "Identification of Cys139 and Glu207 as Catalytically Important Groups in the Active Site of Isopentenyldiphosphate:Dimethyl-allyldiphosphate Isomerase." Biochemistry 1994, 33, 4212-4217.
Song, L.; Poulter, C.D. "Yeast Farnesyl Diphosphate Synthase. Site-Directed Mutagenesis of Residues in Highly-Conserved Prenyltransferase Domains I and II." Proc. Natl. Acad. Sci. USA 1994, 91, 3044-3048.
Mookhtiar, K.A.; Kalinowski, S.S.; Zhang, D.; Poulter, C.D. "Yeast Squalene Synthase. A Mechanism for Addition of Substrates and Activation by NADPH." J. Biol. Chem. 1994, 269, 11201-11207.
Chen, A.; Zhang, D.; Poulter, C.D. "(S)-Geranylgeranylglyceryl Phosphate Synthase. Purification and Characterization of the First Pathway-Specific Enzyme in Archaebacterial Membrane Lipid Biosynthesis." J. Biol. Chem. 1993, 268, 21701-21705.
Mayer, M.P.; Prestwich, G.D.; Dolence, J.M.; Bond, P.D.; Wu, H.-y.; Poulter, C.D. "Protein Farnesyltransferase. Expression and Immunoaffinity Purification of the Heterodimeric Protein from Saccharomyces cerevisiae." Gene 1993, 132, 41-47.
Zhang, D.; Poulter, C.D. "Analysis and Purification of Phosphorylated Isoprenoids by Reversed-Phase HPLC." Anal. Biochem. 1993, 213, 356-361.
Zhang, D.; Jennings, S.M.; Robinson, G.W.; Poulter, C.D. "Yeast Squalene Synthase. Expression, Purification and Characterization of Soluble Recombinant Enzyme." Arch. Biochem. Biophys. 1993, 304, 133-143.
Zhang, D.; Poulter, C.D. "Biosynthesis of Archaebacterial Lipids in Halobacterium halobium and Methanobacterium thermoautotrophicum." J. Org. Chem. 1993, 58, 3919-3922.
Chen, A.-J.; Poulter, C.D. "Purification and Characterization of Farnesyl Diphosphate/ Geranylgeranyl Diphosphate Synthase. A Thermostable Bifunctional Enzyme from Methanobacterium thermoautotrophicum." J. Biol. Chem. 1993, 268, 11002-11007.
Zhang, D.L.; Poulter, C.D. "Biosynthesis of Archaebacterial Ether Lipids. Formation of Ether Linkages by Prenyltransferases." J. Am. Chem. Soc. 1993, 115, 1270-1277.
Davisson, V.J.; Poulter, C.D. "Farnesyl Diphosphate Synthase. Interplay between Substrate Topology, Stereochemistry, and Regiochemistry in Electrophilic Alkylations." J. Am. Chem. Soc. 1993, 115, 1245-1260.
Davisson, V.J.; Neal, T.R.; Poulter, C.D. "Farnesyl Diphosphate Synthase. Catalysis of an Intramolecular Prenyl Transfer with Bisubstrate Analogs." J. Am. Chem. Soc. 1993, 115, 1235-1245.
Marrero, P.F.; Poulter, C.D.; Edwards, P.A. "Effects of Site Directed Mutagenesis of the Highly Conserved Aspartate Residues in Domain II of Farnesyl Diphosphate Synthase Activity." J. Biol. Chem. 1992, 267, 21873-21878.
Lu, X.J.; Christensen, D.J.; Poulter, C.D. "Isopentenyl Diphosphate Isomerase. Irreversible Inhibition by 3-Methyl-3,4-epoxybutyl Diphosphate." Biochemistry 1992, 31, 9955-9960.
Mayer, M.P.; Hahn, F.M.; Stillman, D.J.; Poulter, C.D. "Disruption and Mapping of IDI1. The Gene for Isopentenyl Diphosphate Isomerase in Saccharomyces cerevisiae." Yeast 1992, 8, 743-748.
Gebler, J.C.; Woodside, A.B.; Poulter, C.D. "Dimethylallyltryptophan Synthase. An Enzyme Catalyzed Electrophilic Aromatic Substitution." J. Am. Chem. Soc. 1992, 114, 7354-7360.
Math, S.K.; Hearst, J.E.; Poulter, C.D. "The crtE Gene in Erwinia herbicola Encodes Geranylgeranyl Diphosphate Synthase." Proc. Natl. Acad. Sci. USA 1992, 89, 6761-6764.
Gebler, J.C.; Poulter, C.D. "Purification and Characterization of Dimethylallyl Tryptophan Synthase from Claviceps purpurea." Arch. Biochem. Biophys. 1992, 296, 308-313.
Street, I.P.; Coffman, H.R.; Poulter, C.D. "Isopentenyl Diphosphate Isomerase. Site-Directed Mutagenesis of Cys139 Using "Counter" PCR Amplification of an Expression Plasmid." Tetrahedron 1991, 47, 5919-5924.
Poulter, C.D.; Mautz, D. "Solvolysis of Allylic Phosphorothioate Esters. A Mechanistic Study of the Thiono ® Thiolo Rearrangement." J. Am. Chem. Soc. 1991, 113, 4895-4903.
Ding, V.D.-H.; Sheares, B.T.; Bergstrom, J.D.; Ponpipom, M.M.; Perez, L.B.; Poulter, C.D. "Purification and Characterization of Recombinant Human Farnesyl Diphosphate Synthetase Expressed in E. coli." Biochem. J. 1991, 275, 61-65.
Davis, D.; Poulter, C.D. "¹H-¹⁵N NMR studies of E. coli tRNA^Phe from HisT Mutants: A Structural Role for Pseudouridine." Biochemistry 1991, 30, 4223-4231.
Brown, M.J.; Milano, P.D.; Lever, D.C.; Epstein, W.W.; Poulter, C.D. "Prenylated Proteins. A Convenient Synthesis of Farnesyl Cysteinyl Thioethers." J. Am. Chem. Soc. 1991, 113, 3176-3177.
Street, I.P.; Christensen, D.J.; Poulter, C.D. "Hydrogen Exchange During the Enzyme Catalyzed Isomerization of Isopentenyl Diphosphate and Dimethylallyl Diphosphate." J. Am. Chem. Soc. 1990, 112, 8577-8578.
Schafer, W.R.; Trueblood, C.E.; Yang, C.-C.; Mayer, M.P.; Rosenberg,S.; Poulter, C.D.; Kim, S.-H.; Rine, J. "Enzymatic Coupling of Cholesterol Intermediates to a Mating Pheromone Precursor and to the Ras Protein." Science 1990, 249, 1133-1139.
Street, I.P.; Poulter, C.D. "Isopentenyldiphosphate: Dimethylallyldiphosphate Isomerase: Construction of a High-Level Heterologous Expression System for the Gene from Saccharomyces cerevisiae and Identification of an Active-Site Nucleophile." Biochemistry 1990, 29, 7531-7538.
Poulter, C.D. "Biosynthesis of Non-Head-to-Tail Terpenes. Formation of 1'-1 and 1'-3 Linkages." Acc. Chem. Res. 1990, 23, 70-77.
Zhang, D.L.; Daniels, L.; Poulter, C.D. "Biosynthesis of Archaebacterial Membranes. Formation of Isoprene Ethers by a Prenyl Transfer Reaction." J. Am. Chem. Soc. 1990, 112, 1264-1265.
Poulter, C.D. "Isopentenyl Diphosphate to Squalene. Enzymology and Inhibition." In The Biochemistry of Cell Walls and Membranes in Fungi; Chapter 12, P.J. Kuhn, A.P.J. Trinci, M.J. Jung, M.W. Goosey, L.G. Copping, Eds.; Springer-Verlag: Berlin, 1990, 169-188.
Mautz, D.; Davisson, V.J.; Poulter, C.D. "Synthesis of O-Geranyl (1-Thio)diphosphate." Tetrahedron Lett. 1989, 30, 7333-7336.
Huang, Z.; Poulter, C.D. "Isoshowacene. A New C₃₁ Hydrocarbon from Botryococcus braunii var. Showa." Phytochemistry1989, 28, 3043-3046.
Anderson, M.S.; Yarger, J.G.; Burck, C.L.; Poulter, C.D. "Farnesyl Diphosphate Synthetase. Molecular Cloning, Sequence, and Expression of an Essential Gene from Saccharomyces cerevisiae." J. Biol. Chem. 1989, 264, 19176-19184.
Anderson, M.S.; Muehlbacher, M.; Street, I.P.; Proffitt, J.; Poulter, C.D. "Isopentenyl Diphosphate:Dimethylallyl-Diphosphate Isomerase. An Improved Purification of the Enzyme and Isolation of the Gene from Saccharoymces cerevisiae." J. Biol. Chem. 1989, 264, 19169-19175.
Sherman, M.M.; Petersen, L.; Poulter, C.D. "Isolation and Characterization of Isoprene Mutants of Escherichia coli." J. Bacteriology 1989, 171, 3619-3628.
Huang, Z.; Poulter, C.D. "Tetramethylsqualene. A New Triterpene from Botryococcus braunii var. Showa." Phytochemistry 1989, 28, 1467-1470.
Poulter, C.D.; Muehlbacher, M.; Davis, D.R. "Isopentenyl Diphosphate Isomerase. Mechanism of Active-Site-Directed Irreversible Inhibition by 3-(Fluoromethyl)-3-butenyl Diphosphate." J. Am. Chem. Soc. 1989, 111, 3740-3742.
Poulter, C.D.; Capson, T.L.; Thompson, M.D.; Bard, R.M. "Squalene Synthetase. Inhibition by Ammonium Analogs of Carbocationic Intermediates in the Conversion of Presqualene Diphosphate to Squalene." J. Am. Chem. Soc. 1989, 111, 3734-3739.
Davis, D.R.; Yamaizumi, Z.; Nishimura, S.; Poulter, C.D. "¹⁵N Labeled 5S RNA. Identification of Uridine Base Pairs in E. coli 5S RNA by ¹H-¹⁵N Multiple Quantum NMR." Biochemistry 1989, 28, 4105-4108.
Huang, Z.; Poulter, C.D. "Stereochemical Studies of Botryococcene Biosynthesis: Analogies between 1'-1 and 1'-3 Condensation in the Isoprenoid Pathway." J. Am. Chem. Soc. 1989, 111, 2713-2715.
Capson, T.L.; Thompson, M.D.; Dixit, V.M.; Gaughan, R.G.; Poulter, C.D. "Synthesis of Ammonium Analogs of Carbocationic Intermediates in the Conversion of Presqualene Diphosphate to Squalene." J. Org. Chem. 1988, 53, 5903-5908.
Huang, Z.; Poulter, C.D. "Isobraunicene, Wolficene, and Isowolficene. New Cyclic 1'-3 Fused Isoprenoids from Botryococcus braunii." J. Org. Chem. 1988, 53, 5390-5392.
Gmeiner, W.H.; Poulter, C.D. "NMR Studies of Nucleic Acids. Deuterium Isotope Effects of ¹³C Chemical Shifts in Hydrogen Bonded Complexes of Pyrimidines and Purines." J. Am. Chem. Soc. 1988, 110, 7640-7647.
Muehlbacher, M.; Poulter, C.D. "Isopentenyl-Diphosphate Isomerase. Inactivation of the Enzyme with Active-Site-Directed Inhibitors and Transition State Analogs." Biochemistry 1988, 27, 7315-7328.
Huang, Z.; Poulter, C.D. "Braunicene. Absolute Stereochemistry of the Cyclohexane Ring." J. Org. Chem. 1988, 53, 4089-4094.
Huang, Z.; Poulter, C.D.; Wolf, F.F.; Somers, T.C.; White, J.D. "Braunicene. A Novel Cyclic C₃₂ Isoprenoid from Botryococcus braunii." J. Am. Chem. Soc. 1988, 110, 3959-3964.
Poulter, C.D.; Aoki, T.; Daniels, L. "Biosynthesis of Isoprenoid Membranes in the Methanogenic Archaebacterium Methanospirillum hungatei." J. Am. Chem. Soc. 1988, 110, 2620-2624.
Gmeiner, W.H.; Poulter, C.D. "An Efficient Synthesis of [8-¹³C]Adenine." J. Org. Chem. 1988, 53, 1322-1323.
Muehlbacher, M.; Poulter, C.D. "Regioselective Opening of Simple Epoxides with Diisopropylamine Trihydrofluoride." J. Org. Chem. 1988, 53, 1026-1030.
Davisson, V.J.; Sharp, T.R.; Poulter, C.D. "Negative Ion Fast Atom Bombardment Mass Spectrometry of Isoprenoid Diphosphates and Related Analogs." Bioorg. Chem. 1988, 16, 111-123.
Woodside, A.B.; Huang, Z.; Poulter, C.D. "Geranyl Diphosphate." Org. Syn. 1987, 66, 211-219.
Stremler, K.E.; Poulter, C.D. "Methane and Difluoromethanediphosphonate Analogs of Geranyl Diphsophate: Hydrolysis-Inert Alternate Substrates." J. Am. Chem. Soc. 1987, 109, 5542-5544.
McClard, R.W.; Fujita, T.S.; Stremler, K.E.; Poulter, C.D. "Novel Phosphonylphosphinyl (P-C-P-C-) Analogs of Biochemically Interesting Diphosphates. Synthesis and Properties of P-C-P-C- Analogs of Isopentenyl Diphosphate and Dimethylallyl Diphosphate." J. Am. Chem. Soc. 1987, 109, 5544-5545.
Davisson, V.J.; Davis, D.R.; Dixit, V.M.; Poulter, C.D. "Synthesis of Nucleotide 5'-Diphosphates from 5'-O-Tosyl Nucleosides." J. Org. Chem. 1987, 52, 1794-1801.
Griffey, R.H.; Davis, D.R.; Yamaizumi, Z.; Nishimura, S.; Hawkins, B.L.; Poulter, C.D. "¹⁵N Labeled tRNA. Identification of 4-Thiouridine in Escherichia coli tRNA^er and tRNA^yr by ¹H-¹⁵N Two-Dimensional NMR Spectroscopy." J. Biol. Chem. 1986, 261, 12074-12078.
Davisson, V.J.; Woodside, A.B.; Neal, T.R.; Stremler, K.E.; Muehlbacher, M.; Poulter, C.D. "Phosphorylation of Isoprenoid Alcohols." J. Org. Chem. 1986, 51, 4768-4779.
Davisson, V.J.; Zabriskie, T.M.; Poulter, C.D. "Radiolabeled Allylic Isoprenoid Pyrophosphates: Synthesis, Purification, and Determination of Specific Activity." Bioorg. Chem. 1986, 14, 46-54.
Davis, D.R.; Griffey, R.H.; Yamaizumi, Z.; Nishimura, S.; Poulter, C.D. "¹⁵N Labeled tRNA. Identification of Dihydrouridine in E. coli tRNA^M^et, tRNA^Lys, and tRNA^Phe by ¹H-¹⁵N Two-Dimensional NMR." J. Biol. Chem. 1986, 261, 3584-3587.
Aoki, T.; Poulter, C.D. "Archaebacterial Isoprenoids. Synthesis of 2,3-Di-O-phytanyl-sn-glycerol and its 1,2-Isomer." J. Org. Chem. 1985, 50, 5634-5636.
Muehlbacher, M.; Poulter, C.D. "Isopentenyl Pyrophosphate: Dimethylallyl Pyrophosphate Isomerase. Irreversible Inhibition of the Enzyme by Active-Site Directed Covalent Attachment." J. Am. Chem. Soc. 1985, 107, 8307-8308.
Heathcock, C.H.; Finkelstein, B.L.; Aoki, T.; Poulter, C.D. "Stereostructure of the Archaebacterial C₄₀ Diol." Science 1985, 229, 862-864.
Bartlett, D.L.; King, C.-H.R.; Poulter, C.D. "An Affinity Column for the Purification of Prenyltransferases." Anal. Biochem. 1985, 149, 507-515.
Davisson, V.J.; Neal, T.R.; Poulter, C.D. "Farnesyl Pyrophosphate Synthetase. A Case for Common Electrophilic Mechanisms for Prenyltransferases and Terpene Cyclases." J. Am. Chem. Soc. 1985, 107, 5277-5279.
Griffey, R.H.; Davis, D.; Yamaizumi, Z.; Bax, A.; Nishimura, S.; Hawkins, B.L.; Poulter, C.D. "¹⁵N Labeled E. coli tRNA^M^et, tRNA^Glu, tRNA^Tyr, and tRNA^Phe. Double Resonance and Two Dimensional NMR of H-N1 Units in Pseudouridine." J. Biol. Chem. 1985, 260, 9734-9741.
Yang, T.-H.; Zabriskie, T.M.; Poulter, C.D. "Reversed-Phase High Pressure Liquid Chromatography of C₅ to C₂₀ Isoprenoid Benzoates and Naphthoates." Meth. Enzymol. 1985, 111, 252-263.
Bartlett, D.L.; King, C.-H.R.; Poulter, C.D. "Purification of Farnesyl Pyrophosphate Synthetase by Affinity Chromatography." Meth. Enzymol. 1985,110, 171-184.
Davisson, V.J.; Woodside, A.B.; Poulter, C.D. "Synthesis of Allylic and Homoallylic Isoprenoid Pyrophosphates." Meth. Enzymol. 1985, 110, 130-144.
Sagami, H.; Ogura, K.; Weiner, A.; Poulter, C.D. "Effect of Zinc Ions on Farnesyl Pyrophosphate Synthetase Activity." Biochemistry Intl. 1984, 8, 661-667.
Dixit, V.M.; Poulter, C.D. "Convenient Syntheses of Adenosine 5'-Diphosphate, Adenosine 5'-Methylenediphosphonate, and Adenosine 5'-Triphosphate." Tetrahedron Lett. 1984, 25, 4055-4058.
Capson, T.L.; Poulter, C.D. "A Facile Synthesis of Primary Amines from Carboxylic Acids by the Curtius Rearrangement." Tetrahedron Lett. 1984, 25, 3515-3518.
Yang, T.-H.; Zabriskie, T.M.; Poulter, C.D. "Investigation of Isoprenoid Benzoates and Naphthoates by Reversed-Phase Liquid Chromatography. Isocratic Elution Characteristics of Benzoates and Naphthoates of C₅-C₂₀ Terpenoid Alcohols." J. Chromatography 1984, 312, 121-132.
Griffey, R.H.; Poulter, C.D. "Detection of the Imino Hydrogen Bond in G-C Pairs by ¹H and ¹⁵N Nuclear Magnetic Resonance Spectroscopy." Tetrahedron Lett. 1983, 24, 4067-4070.
Griffey, R.H.; Poulter, C.D.; Bax, A.; Hawkins, B.L.; Yamaizumi, Z.; Nishimura, S. "Multiple Quantum Two-Dimensional ¹H-¹⁵N Nuclear Magnetic Resonance Spectroscopy: Chemical Shift Correlation Maps for Exchangeable Imino Protons of Escherichia coli tRNA^et in Water." Proc. Natl. Acad. Sci. 1983, 80, 5895-5897.
Griffey, R.H.; Poulter, C.D. "Efficient Syntheses of [3-¹⁵N]Uracil and [3-¹⁵N]Thymine." Nucleic Acids Research 1983, 11, 6497-6504.
Griffey, R.H.; Poulter, C.D.; Yamaizumi, Z.; Nishimura, S.; Hawkins, B.L. "¹H NMR Studies of Nitrogen-15-Labeled Escherichia coli tRNA^et. Assignments of Imino Resonances for Uridine-Related Bases by ¹H-¹⁵N Heteronuclear Double Resonance Difference Spectroscopy." J. Am. Chem. Soc. 1983, 105, 143-145.
Sandifer, R.M.; Thompson, M.D.; Gaughan, R.G.; Poulter, C.D. "Squalene Synthetase. Inhibition by an Ammonium Analogue of a Carbocationic Intermediate in the Conversion of Presqualene Pyrophosphate to Squalene." J. Am. Chem. Soc. 1982, 104, 7376-7378.
Griffey, R.H.; Poulter, C.D.; Yamaizumi, Z.; Nishimura, S.; Hurd, R.E. "¹H NMR Studies of ¹⁵N-Labeled Escherichia coli tRNA^M^et. An Unambiguous Assignment for the G-U Pair and Detection of a Uridine Resonance at 11.4 ppm." J. Am. Chem. Soc. 1982, 104, 5811-5813.
Griffey, R.H.; Poulter, C.D.; Yamaizumi, Z.; Nishimura, S.; Hurd, R.E. "¹H NMR Studies of ¹⁵N-Labeled Escherichia coli tRNA^M^et. Use of ¹J₁_H-₁₅_N Couplings to Identify Imino Resonances of Uridine-Related Bases." J. Am. Chem. Soc. 1982, 104, 5810-5811.
Poulter, C.D.; King, C.-H.R. "Model Studies of Terpene Biosynthesis. A Stepwise Mechanism for Cyclization of Nerol to a-Terpineol." J. Am. Chem. Soc. 1982, 104, 1422-1424.
Poulter, C.D.; King, C.-H.R. "Model Studies of Terpene Biosynthesis. Stereospecific Cyclization of N-Methyl-(S)-4-([1'-²H]neryloxy)pyridinium Methyl Sulfate to a-Terpineol." J. Am. Chem. Soc. 1982, 104, 1420-1422.
King, C.-H.R.; Poulter, C.D. "Model Studies of Terpene Biosynthesis. Intermolecular 1'-2 Electrophilic Condensation of 3-Methyl-2-butenyl Acetate." J. Am. Chem. Soc. 1982, 104, 1413-1420.
Mash, E.A.; Gurria, G.M.; Poulter, C.D. "Farnesyl Pyrophosphate Synthetase. Evidence for a Rigid Geranyl Cation-Pyrophosphate Anion Pair." J. Am. Chem. Soc. 1981, 103, 3927-3929.
Poulter, C.D.; Wiggins, P.L.; Le, A.T. "Farnesyl Pyrophosphate Synthetase. A Stepwise Mechanism for the 1'-4 Condensation Reaction." J. Am. Chem. Soc. 1981, 103, 3926-3927.
Poulter, C.D.; Argyle, J.C.; Mash, E.A.; Laskovics, G.M.; Wiggins, P.L.; King, C.R. "Inhibitors of Isoprenoid Biosynthesis." In Regulation of Insect Development and Behavior; Chapter 3, “Chemistry and Biochemistry of Juvenile Hormones”, Wroclaw Technical University Press: 1981, pp. 149-162.
Poulter, C.D.; Rilling, H.C. "Conversion of Farnesyl Pyrophosphate to Squalene." In Biosynthesis of Isoprenoid Compounds; Volume 1, Chapter 8, J.W. Porter, Ed.; John Wiley & Sons: New York, 1981, pp. 414-441.
Poulter, C.D.; Rilling, H.C. "Prenyl Transferases and Isomerase." In Biosynthesis of Isoprenoid Compounds; Volume 1, Chapter 4, J.W. Porter, Ed.; John Wiley & Sons: New York, 1981, pp. 162-224.
Dixit, V.M.; Laskovics, F.M.; Noall, W.I.; Poulter, C.D. "Tris-(tetra-n-butylammonium) Hydrogen Pyrophosphate. A New Reagent for the Preparation of Allylic Pyrophosphate Esters." J. Org. Chem. 1981, 46, 1967-1969.
Poulter, C.D.; Wiggins, P.L.; Plummer, T.L. "Synthesis of Fluorinated Analogues of Geraniol." J. Org. Chem. 1981, 46, 1532-1538.
Laskovics, F.M.; Poulter, C.D. "Prenyltransferase. Determination of the Binding Mechanism and Individual Kinetic Constants for Farnesyl Pyrophosphate Synthetase by Rapid Quench and Isotope Partitioning Experiments." Biochemistry 1981, 20, 1893-1901.
Poulter, C.D.; Mash, E.A.; Argyle, J.C.; Muscio, O.J.; Rilling, H.C. "Farnesyl Pyrophosphate Synthetase. Mechanistic Studies of the 1'-4 Coupling Reaction in the Terpene Biosynthetic Pathway." J. Am. Chem. Soc. 1979, 101, 6761-6763.
Laskovics, F.M.; Krafcik, J.M.; Poulter, C.D. "Prenyltransferase. Kinetic Studies of the 1'-4 Coupling Reaction with Avian Liver Enzyme." J. Biol. Chem. 1979, 254, 9458-9463.
Gaughan, R.G.; Poulter, C.D. "Non-Head-to-Tail Monoterpenes. Synthesis of (S)-Lyratol and (S)-Lyratyl Acetate from (1R,3R)-Chrysanthemic Acid." J. Org. Chem. 1979, 44, 2441-2444.
Poulter, C.D.; Livingston, C.L. "[3-¹⁵N]-2',3',5'-Tri-O-benzoyluridine. Detection of Hydrogen Bonding in A-U Base Pairs by ¹⁵N NMR." Tetrahedron Lett. 1979, 755-758.
Poulter, C.D.; Rilling, H.C. "The Prenyl Transfer Reaction. Enzymatic and Mechanistic Studies of the 1'-4 Coupling Reaction in the Terpene Biosynthetic Pathway." Acc. Chem. Res. 1978, 11, 307-313.
Poulter, C.D.; Argyle, J.C.; Mash, E.A. "Farnesyl Pyrophosphate Synthetase. Mechanistic Studies of the 1'-4 Coupling Reaction with 2-Fluorogeranyl Pyrophosphate." J. Biol. Chem. 1978, 253, 7227-7233.
Teranishi, R.; Flath, R.A.; Mon, T.R.; Poulter, C.D.; Kikuchi, M. "Volatile Constituents of California Sage Brush." Fragrance J. 1978, 6, 45-47.
Roberts, J.L.; Poulter, C.D. "2',3',5'-Tri-O-benzoyl[4-¹³C]uridine. An Efficient, Regiospecific Synthesis of the Pyrimidine Ring." J. Org. Chem. 1978, 43, 1547-1550.
Poulter, C.D.; Satterwhite, D.M. "Mechanism of the Prenyl Transfer Reaction. Studies with (E)- and (Z)-3-Trifluoromethyl-2-buten-1-yl Pyrophosphate." Biochemistry 1977, 16, 5470-5478.
Roberts, J.L.; Borromeo, P.S.; Poulter, C.D. "Addition of Eschenmoser's Salt to Ketone, Ester, and Lactone Enolates. A Convenient Synthesis of a-Methylene Carbonyls via Mannich Intermediates." Tetrahedron Lett. 1977, 1621-1624.
Roberts, J.L.; Borromeo, P.S.; Poulter, C.D. "Addition of Grignard and Lithium Reagents to Eschenmoser's Salt. A Convenient Synthesis of Terminal Olefins." Tetrahedron Lett. 1977, 1299-1302.
Poulter, C.D.; Hughes, J.M. "Model Studies of the Biosynthesis of Non-Head-to-Tail Terpenes. Stereochemistry of the Head-to-Head Rearrangement." J. Am. Chem. Soc. 1977, 99, 3830-3837.
Poulter, C.D.; Hughes, J.M. "Model Studies of the Biosynthesis of Non-Head-to-Tail Terpenes. Stereochemistry of Ionization for N-Methyl-4-[(1S,1'R,3'R)-[1-²H]Chrysanthemyloxy]pyridinium Iodide." J. Am. Chem. Soc. 1977, 99, 3824-3829.
Poulter, C.D.; Marsh, L.L.; Hughes, J.M.; Argyle, J.C.; Satterwhite, D.M.; Goodfellow, R.J.; Moesinger, S.G. "Model Studies of the Biosynthesis of Non-Head-to-Tail Terpenes. Rearrangements of the Chrysanthemyl System." J. Am. Chem. Soc. 1977, 99, 3816-3823.
Poulter, C.D.; Argyle, J.C.; Mash, E.A. "Prenyltransferase. New Evidence for an Ionization-Condensation-Elimination Mechanism with 2-Fluorogeranyl Pyrophosphate." J. Am. Chem. Soc. 1977, 99, 957-959.
Poulter, C.D.; Satterwhite, D.M.; Rilling, H.C. "Prenyltransferase. The Mechanism of the Reaction." J. Am. Chem. Soc. 1976, 98, 3376-3377.
Poulter, C.D.; Rilling, H.C. "Prenyltransferase. The Mechanism of the Reaction." Biochemistry 1976, 15, 1079-1083.
Epstein, W.W.; McGee, L.R.; Poulter, C.D.; Marsh, L.L. "Mass Spectral Data for Gas Chromatograph--Mass Spectral Identification of Some Irregular Monoterpenes." J. Chem. and Engr. Data 1976, 21, 500-502.
Spicer, L.D.; Poulter, C.D. "Isotopes as Probes for Determining Reaction Mechanisms." In Physical Chemistry. An Advanced Treatise; Vol. 7, H. Eyring, D. Henderson, W. Jost, Ed.; Academic Press: 1975.
Poulter, C.D.; Frederick, G.D. "Uracil and its 4-Hydroxy-1(H) and 2-Hydroxy-3(H) Protomers. pK_a's and Equilibrium Constants." Tetrahedron Lett. 1975, 2171-2174.
Frederick, G.D.; Poulter, C.D. "Extension of the H_A Acidity Function into Oleum Mixtures." J. Am. Chem. Soc. 1975, 97, 1797-1801.
Poulter, C.D.; Muscio, O.J.; Goodfellow, R.J. "Model Studies of Terpene Biosynthesis. Synthesis of (+)-2-[trans-2'-(2'-Methylpropenyl)cyclopropyl]propan-2-ol." J. Org. Chem. 1975, 40, 139-140.
Poulter, C.D.; Spillner, C.J. "The (trans-2'-Methylcyclopropyl)methyl System. Stereochemistry of Ionization, Rearrangement, and Solvent Capture." J. Am. Chem. Soc. 1974, 96, 7591-7593.
Muscio, O.J.; Poulter, C.D. "Model Studies in Terpene Biosynthesis. Synthesis and Absolute Configuration of (+)-trans-2,2-Dimethyl-3-(2'-methyl-propenyl)cyclobutanol." J. Org. Chem. 1974, 39, 3288-3291.
Poulter, C.D.; Muscio, O.J.; Goodfellow, R.J. "Biosynthesis of Head-to-Head Terpenes. Carbonium Ion Rearrangements Which Lead to Head-to-Head Terpenes." Biochemistry 1974, 13,1530-1538.
Poulter, C.D. "Model Studies in Terpene Biosynthesis." Agric. and Food Chem. 1974, 22, 167-173.
Epstein, W.W.; Poulter, C.D. "A Survey of Some Irregular Monoterpenes and their Biogenetic Analogies to Presqualene Alcohol." Phytochemistry 1973, 12, 737-747.
Poulter, C.D.; Anderson, R.B. "Direct Observation of Uracil Dication and Related Derivatives." Tetrahedron Lett. 1972, 3823-3826.
Poulter, C.D.; Muscio, O.J.; Spillner, C.J.; Goodfellow, R.J. "Model Studies of Terpene Biosynthesis. Cationic Rearrangements Leading to Head-to-Head Terpenes." J. Am. Chem. Soc. 1972, 94, 5921-5923.
Poulter, C.D. "Model Studies of Terpene Biosynthesis. Stereoselective Ionization of N-Methyl-4-[(aS,1R,3R)-chrysanthemyloxy]pyridinium-d₁ Iodide." J. Am. Chem. Soc. 1972, 94, 5515-5516.
Poulter, C.D.; Goodfellow, R.J.; Epstein, W.W. "The Absolute Configuration of Santolina Alcohol from Ormenis multicaulis." Tetrahedron Lett. 1972, 71-74.
Poulter, C.D.; Moesinger, S.G.; Epstein, W.W. "Solvolysis of N-Methyl-4-(chrysanthemyloxy)- pyridinium Iodide--A Model for Non-Head-to-Tail Monoterpene Biosynthesis." Tetrahedron Lett. 1972, 67-70.
Poulter, C.D.; Winstein, S. "The a,a,2,2,3,3-Hexamethylcyclopropylcarbinyl System. A Study of Carbonium Ion Behavior in Nucleophilic and Superacid Solvents." J. Am. Chem. Soc. 1972, 94, 2297-2305.
Poulter, C.D.; Boikess, R.S.; Brauman, J.I.; Winstein, S. "Shielding Effects of a Cyclopropane Ring." J. Am. Chem. Soc. 1972, 94, 2291-2296.
Poulter, C.D.; Dickson, R.B. "Stereospecific ⁵J₁_H-₁_H and ⁶J₁_H-₁_H Couplings in 3-Methyl-3-azabicyclo 3.1.0]hexan-2,4-dione." Tetrahedron Lett. 1971, 2255-2258.
Rilling, H.C.; Poulter, C.D.; Epstein, W.W.; Larsen, B. "Studies on the Mechanism of Squalene Biosynthesis. Presqualene Pyrophosphate, Stereochemistry and a Mechanism for Its Conversion to Squalene." J. Am. Chem. Soc. 1971, 93, 1783-1785.
Dauben, W.G.; Poulter, C.D.; Suter, C. "Photoisomerizations of cis- and trans-3-Methylene-cyclodecene." J. Am. Chem. Soc. 1970, 92, 7408-7412.
Poulter, C.D.; Winstein, S. "Stereospecific Homoallylic Ring Expansions and Contractions." J. Am. Chem. Soc. 1970, 92, 4282-4288.
Poulter, C.D.; Friedrich, E.C.; Winstein, S. "Stereospecific Cationic Rearrangements of syn- and anti-Bicyclo[6.1.0]nonane Derivatives." J. Am. Chem. Soc. 1970, 92, 4274-4281.
Poulter, C.D.; Friedrich, E.C.; Winstein, S. "The Stereochemistry of the Methylene Iodide-Zinc-Copper Couple Methylenation of Cyclic Allylic Alcohols." J. Am. Chem. Soc. 1969, 91, 6892-6894.
Poulter, C.D.; Winstein, S. "Solvolysis and Degenerate Cyclopropylcarbinyl-Cyclopropylcarbinyl Rearrangement of a Hexamethylcyclopropylcarbinyl System." J. Am. Chem. Soc. 1969, 91, 3650-3652.
Poulter, C.D.; Winstein, S. "The Cyclopropylcarbinyl-Allyl Rearrangement of a Hexamethyl-cyclopropylcarbinyl System." J. Am. Chem. Soc. 1969, 91, 3649-3650.
Dauben, W.G.; Poulter, C.D. "The Solvolysis of 1-Chlorobicyclo[3.3.1]nonane." J. Org. Chem. 1968, 33, 1237-1239.
Dauben, W.G.; Poulter, C.D. "The Addition of Methanol to Some Bicyclobutanes." Tetrahedron Lett. 1967, 3021-3025.

Poulter Group Publications

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