49) Srinivas R. Paladugu, Chintelle K. James and Ryan E. Looper “A direct C11 alkylation strategy on the saxitoxin core; a synthesis of (+)-11-Saxitoxinethanoic acid” submitted, 2019

 48) Catherine M. Serrano, Hariprasada R. Kanna Reddy, Daniel R. Eiler, Michael R. Koch, Louis R. Barrows, Ryan T. Vanderlinden,  Charles A. Testa, Paul R. Sebahar and Ryan E. Looper* “Unifying aminohexopyranose nucleoside antibiotics; implications for antibiotic design” submitted, 2019

 47Dustin L. Williams, Scott R. Smith, R. Tyler Epperson, Brittany R. Peterson and Ryan E. Looper  “Growth Substrate May Influence Biofilm Susceptibility to Antibiotics” PLOS One, 2019, in press.

 46) Williams, Dustin L.; Epperson, Richard T.; Ashton, Nicholas N.; Taylor, Nicholas B.; Kawaguchi, Brooke; Olsen, Raymond E.; Haussener, Travis J.; Sebahar, Paul R.; Allyn, Gina; Looper, Ryan E.  “In vivo analysis of a first-​in-​class tri-​alkyl norspermidine-​biaryl antibiotic in an active release coating to reduce the risk of implant-​related infection” Acta Biomaterialia, 2019  in press. PMID: 30710710

 45Williams, Dustin L.; Epperson, Richard T.; Ashton, Nicholas N.; Taylor, Nicholas B.; Kawaguchi, Brooke; Olsen, Raymond E.; Haussener, Travis J.; Sebahar, Paul R.; Allyn, Gina; Looper, Ryan E. “In Vitro Testing of a First-In-Class Tri-alkylnorspermidine-biaryl Antibiotic in an Anti-biofilm Silicone Coating” Acta Biomaterialia 2019 in press. PMID:30769135

 44Vaden, R. M.; Guillen, K. P.; Salvant, J. M.; Santiago, C. B.; Gibbons, J. B.; Pathi, S. S.; Arunachalam, S.; Sigman, M. S.; Looper, R. E.; Welm, B. E., A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A. ACS Chem. Biol. 2019,14 (1), 106-117.  PMID: 30571086

 43) Vaden, R. M.; Guillen, K. P.; Salvant, J. M.; Santiago, C. B.; Gibbons, J. B.; Pathi, S. S.; Arunachalam, S.; Sigman, M. S.; Looper, R. E.; Welm, B. E., A Cancer-Selective Zinc Ionophore Inspired by the Natural Product Naamidine A. ACS Chem. Biol. 2019,14 (1), 106-117

42) McBrayer, S. K.; Mayers, J. R.; DiNatale, G. J.; Shi, D. D.; Khanal, J.; Chakraborty, A. A.; Sarosiek, K. A.; Briggs, K. J.; Robbins, A. K.; Sewastianik, T.; Shareef, S. J.; Olenchock, B. A.; Parker, S. J.; Tateishi, K.; Spinelli, J. B.; Islam, M.; Haigis, M. C.; Looper, R. E.; Ligon, K. L.; Bernstein, B. E.; Carrasco, R. D.; Cahill, D. P.; Asara, J. M.; Metallo, C. M.; Yennawar, N. H.; Vander Heiden, M. G.; Kaelin, W. G., Jr., Transaminase Inhibition by 2-Hydroxyglutarate Impairs Glutamate Biosynthesis and Redox Homeostasis in Glioma. Cell 2018,175 (1), 101-116.e25

41) Tuomas Laukka, Matti Myllykoski, Ryan E. Looper, Peppi Koivunen “Cancer-associated 2-oxoglutarate analogues modify histone methylation by inhibiting histone lysine demethylasesMol. Biol. 2018, 430, 3081-3092.

40) Spivak, A. M.; Nell, R. A.; Petersen, M.; Martins, L.; Sebahar, P.; Looper, R. E.; Planelles, V., Synthetic Ingenols Maximize Protein Kinase C-Induced HIV-1 Latency Reversal. Antimicrob Agents Chemother 2018,62 (11).

39) Philip B, Yu DX, Silvis MR, Shin CH, Robinson JP, Robinson GL, Welker AE, Angel SN, Tripp SR, Sonnen JA, VanBrocklin MW, Gibbons RJ, Looper RE, Colman H, Holmen SL.Mutant IDH1 Promotes Glioma Formation In VivoCell Rep. 2018, 23, 1553-1564.

 38) Divya Bharat, Rafaela Ramos Mororo Cavalcanti, Chrissa Petersen, Nathan Bageye, Brett Ronald Cutler, Marcella Melo Assis Costa, Renata Kelly Luna Gomes Ramos, Marina Ramos Ferreira, Youyou Li, Leena P Bharath, Emma Toolson, Paul Sebahar, Ryan E Looper, Thunder Jalili, Namakkal S Rajasekaran, Zhenquan Jia, John David Symons, Pon Velayutham Anandh Babu ”Blueberry metabolites attenuate indices of lipotoxicity-induced endothelial dysfunctionMolecular Nutrition and Food Research. 2018, 62(2), n/a.

 37) Justin M. Salvant, Anne V. Edwards, Daniel Z. Kurek and Ryan E. Looper “Regioselective base-mediated cyclizations of mono-N-acylpropargylguanidines”, J. Org. Chem. 2017, 82, 6958-6967. 

36) Ki-Hyeok Kwon, Anne V. Edwards, Miao Yang and Ryan E. Looper “Exploring hyroamination-cycloaddition-fragmentation sequences to access polycyclicguanidines and vinyl-2-aminoimadazolesTetrahedron. 2017, 73, 6067-6079.

35) Travis J. Haussener, Paul R. Sebahar, Hariprasada K. Reddy, Dustin L. Williams and Ryan E. Looper “A Practical Synthesis of N-alkyl- and N’,N’-dialkyl polyamines”, Tetrahedron Letters. 2016,57, 2845-2848. 

34) Srinivas R. Paladugu and Ryan E. Looper “Preparation of a 1,2-isoxazolidine synthon for the synthesis of zetekitoxin AB.Preparation of a 1,2-isoxazolidine synthon for the synthesis of zetekitoxin AB.Tetrahedron Lett.2015, 56, 6332-6334. PMCID: PMC4649947

33) Joseph B. Gibbons, Justin M. Salvant, Rachel M. Vaden, Bryan E. Welm and Ryan E. Looper “A synthesis of naamidine A and selective access to N2-acyl-2-aminoimidazoles.” J. Org. Chem.2015,80, 10076–10085.

32) Kihyeok Kwon, Travis J. Haussener and Ryan E. Looper “Preparation of mono-Cbz protected guanidines (Potassium carbobenzyloxycyanamide, carbobezyloxycyanamide potassium salt)” Org. Synth. 2015, 92, 91-102. bicyclic guanidines

31)Kaitlin J. Basham, Christopher J. Leonard, Collin Kieffer, Dawne N. Shelton, Vasudev R. Bhonde, Ryan E. Looper, and Bryan E. Welm Dioxin Exposure Blocks Lactation Through a Direct Effect on Mammary Epithelial Cells Mediated by the Aryl Hydrocarbon Receptor RepressorToxicol. Sci. 2015, 143 (1), 36-45. PMCID: PMC4274378

Human phosphoglycerate

 30)Jing Fan, Xin Teng, Ling Liu, Ryan E. Looper and Joshua D. Rabinowitz Human phosphoglycerate dehydrogenase produces the oncometabolite D-2-hydroxyglutarateACS Chemical Biology.2015, 10, 510-516. PMCID:PMC4340346 

Dioxin Exposure

29) Ki-hyeok Kwon, Catherine M. Serrano, Michael Koch, Louis R. Barrows and Ryan E. Looper “Synthesis of bicyclic guanidines via cascade hydroamination /Michael additions of mono-N-acylpropargylguanidines” Organic Letters, 2014, 16, 6048-6051. PMCID:PMC4260634

Image for publication 29

28) Kaitlin J. Basham, Vasudev R. Bhonde, Collin Keiffer, James B. C. Mack, Matthew Hess, Bryan E.  Welm and Ryan E. Looper “Bis-aryloxadiazoles as effective activators of the aromatic hydrocarbon receptorBioorg. Med. Chem. Lett.2014, 24, 2473-2476. PMCID: PMC4086406.

Image for publication 28

27) Julie-Aurore Losman, Ryan Looper, Peppi Koivunen, Sungwoo Lee, Rebekka K. Schneider, Christine McMahon, Glenn Cowley, David Root, Benjamin L. Ebert, and William G. Kaelin Jr. “(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible”Science2013, 339, 1621-1625.

Image for Publication 27

26) Kaitlin J. Basham, Collin Keiffer, Dawne N. Shelton, Chris J. Leonard, Vasudev R. Bhonde, Hariprasad Vankayalapati, Brett Milash, David J. Bearss, Ryan E. Looper, and Bryan E. Welm "Chemical genetic screen reveals a role for desmosomal adhesion in mammary branching morphogenesis." J. Biol. Chem.2013, 228(4), 2261-2270.

Image for publication 26

25) Miao Yang, Shannon Odelberg, Dean Li and Ryan E. Looper "Cationic-Rh(II) complexes for the synthesis of dihydropyrimidines from propargylureas"Tetrahedron 201369, 5744-5750.

Image for publication 25

24) Joseph B. Gibbons, Keith M. Gligorich, Bryan E. Welm and Ryan E. Looper "Synthesis of the reported structures for kealiinines B and C"OrganicLetters 2012, 14, 4734-4737. 

Publication 24

23) Kihyeok Kwon, Travis J. Haussener and Ryan E. Looper "Preparation of mono-Cbz protected guanidines (Potassium carbobenzyloxycyanamide, carbobezyloxycyanamide potassium salt)" Org. Syn. 2015. 92, 91-102.

Publication 23

22) Travis J. Haussener and Ryan E. Looper "An epoxide opening cascade to access the pactamycin core"Organic Letters2012, 14, 3632-3635.

Publication 22

21) Vasudev R. Bhonde and Ryan E. Looper "Carbamic acid, N-[[[(1,1dimethylethoxy)carbonyl]amino](methylthio)methylene]-,1,1-dimethylethyl ester" Encyclopedia of Reagents for Organic Synthesis (eROS), 2013, DOI: 10.1002/047084289X.rn01529.

Publication 21

20) Ryan E. Looper and Robert M. Williams "Efficient Asymmetric Synthesis of N-tert-Butoxycarbonyl-?-Aminoacids using 4-tert-Butoxycarbonyl-5,6-Diphenylmorpholin-2-one: (R)-(N-tert-Butoxycarbonyl)allylglycine"Organic Synthesis2012, 89, 394-403 (Discussion Addendum).

19) Peppi Koivunen, Sungwoo Lee, Chris G. Duncan, Giselle Lopez, Shakti Ramkissoon, Julie Losman, P�ivi Joensuu, Ulrich Bergmann, Stefan Gross, Ryan Looper, Keith Ligon, Roeland Verhaak, Hai Yan, and William G. Kaelin, Jr. "Transformation by the (R) Enantiomer of 2-Hydroxyglutarate Linked to EglN Activation."Nature2012, 483, 484-488.

Publication 19

18) Vasudev R. Bhonde and Ryan E. Looper "A stereocontrolled synthesis of (+)-saxitoxin"J. Am. Chem. Soc.2011, 133, 20172-20174.

Publication 18

17) Catherine M. Serrano and Ryan E. Looper "Rapid assembly of cytimidine through tandem Cu-catalyzed N-aryl amidation reactions"Organic Letters2011, 13, 5000-5003.

Publication 17

16) Ryan E. Looper, Travis J. Haussener and James B. C. Mack "Chlorotrimethylsilane activation of acylcyanamides for the synthesis of mono-N-acylguanidines"J. Org. Chem.2011, 76 (16), 6967-6971.

Publication 16b

15) Morgan J. Gainer, Nitasha R. Bennett, Yu Takahashi and Ryan E. Looper "Regioselective Rh(II)-catalyzed hydroaminations of propargylguanidines"Angew. Chem. Int. Ed. 2011, 50, 684-687.

Publication 15

[Highlighted by the ACIE editors as a "HOT" paper]; [Highlighted in Synfacts 2011, 374.]

14) Robert L. Giles, Richard A. Nkansah and Ryan E. Looper "Synthesis of 2-thio and 2-oxoimidazoles via cascade addition-cycloisomerization reactions of propargyl-cyanamides"J. Org. Chem.2010, 75, 261-264.

Publication 14

13) Mohan R. Kaadige, Ryan E. Looper, Kamalanaadhan Sadhaasivam and Donald E. Ayer "Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity"Proc. Nat. Acad. Sci. USA2009, 106, 14878-14883.

Publication 13

12) Robert L. Giles, John D. Sullivan, Andrew M. Steiner and Ryan E. Looper "Addition-cycloisomerization of propargylcyanamides: efficient access to the 2-amino-imidazole core"Angew. Chem. Int. Ed.2009, 48, 3116-3120. [Highlighted in Synfacts 2009, 725.]

Publication 12

11) John D. Sullivan, Robert L. Giles and Ryan E. Looper "2-aminoimidazoles from Leucetta sponges; synthesis, biology and the emergence of a privileged pharmacophore"Current Bioactive Compounds2009, 5, 39-78.

Publication 11

10) Gregory P. Tochtrop and Ryan E. Looper "Target-oriented synthesis/Strategies for building focused libraries and their uses." pp. 74-87. In Chemical Genomics, Ed. by Haian Fu. Cambridge University Press. 2012.

9) Ryan E. Looper, Daniela Pizzirani and Stuart L. Schreiber "Macrocycloadditions leading to conformationally restricted small molecules"Organic Letter2006, 8, 2063-2066.

8) Ryan E. Looper, Maria T.C. Runnegar and Robert M. Williams "Syntheses of the cylindrospermopsin alkaloids and their toxicological evaluation"Tetrahedron2006, 62, 4549-4562.

7) Ryan E. Looper, Maria T.C. Runnegar and Robert M. Williams "Synthesis of the putative structure of 7-deoxycylindrospermopsin: C7-oxygenation is not required for the inhibition of protein synthesis"Angew. Chem. Int. Ed.2005, 44, 3879-3881.

6) Ryan E. Looper and Robert M. Williams "A concise asymmetric synthesis of the marine hepatotoxin 7-epi-cylindrospermopsin"Angew. Chem. Int. Ed.2004, 43, 2930-2933. [Highlighted by the editors as a "VIP" paper].

5) Ryan E. Looper "Concise Asymmetric Syntheses of the Cylindrospermopsin Alkaloids" Ph.D. Dissertation, 2004, Colorado State University.

4) Ryan E. Looper and Robert M. Williams "Construction of cylindrospermopsin's A ring via an intramolecular oxazinone-N-oxide dipolar cycloaddition"Tetrahedron Lett.2001, 42, 769-771.

3) James R. Vyvyan, Celeste Loitz, Ryan E. Looper, Cheryl S. Mattingly, Emily A. Peterson and Steven T. Staben "Synthesis of aromatic bisabolene natural products via palladium-catalyzed cross couplings of organozinc reagents"J. Org. Chem.2004, 69, 2461-2468.

2) James R. Vyvyan and Ryan E. Looper "Total synthesis of (±)-heliannuol D, an allelochemical from Helianthus annuus"Tetrahedron Lett.2000, 41, 1151-1153.

1) Ryan E. Looper "Studies directed toward the synthesis of allelopathic natural products: the heliannuols, (±)-glandulone A, and related aromatic bisabolene natural products" M.S. Thesis, 1999, Western Washington University.



Last Updated: 8/22/19