Asymmetric Catalysis, Organometallic Chemistry & Organic Synthesis



group retreat 2016 2


Recent Research Highlights

B. P. Woods, M. Orlandi, C.-Y. Huang, M. S. Sigman, A. G. Doyle, J. Am. Chem. Soc. 2017 DOI: 10.1021/jacs.7b03448


 F. D. Toste, M. S. Sigman, S. J. Miller"Pursuit of Noncovalent Interactions for Strategic Site-Selective Catalysis" Acc. Chem. Res. 2017, 50, 609.


  A. J. Neel, M. J. Hilton, M. S. Sigman, F. D. Toste "Exploiting non-covalent π interactions for catalyst design" Nature 2017, 543, 637.

nature rev

 Sevov, C. S.; Hickey, D. P.; Cook, M. E.; Robinson, S. G.; Barnett, S.; Minteer, S. D.*; Sigman, M. S.*; Sanford, M. S.* " Physical Organic Approach to Persistent, Cyclable, Low-Potential Electrolytes for Flow Battery Applications,"J. Am. Chem. Soc2017139, 2924.


Zhang, C.; Tutkowski, B.; DeLuca, R. J.; Joyce, L. A.  WiestO.; Sigman, M. S.* "Palladium-catalyzed enantioselective Heck alkenylation of trisubstituted allylic alkenols: a redox-relay strategy to construct vicinal stereocenters," Chem. Sci.  20178, 2277.


Race, N. J.; Schwalm, C. S.; Nakamuro, T.; Sigman, M. S.* "Palladium-Catalyzed Enantioselective Intermolecular Coupling of Phenols and Allylic Alcohols," J. Am. Chem. Soc. 2016, 138, 15881.

Nick hood

 Eiji, Y.; Hilton, M. J.; Orlandi, M.; Saini, V.; Toste, F.D.; Sigman, M. S.* "Development and Analysis of a Pd(0)-Catalyzed Enantioselective Diarylation of Acrylates Enabled by Chiral Anion Phase Transfer," J. Am. Chem. Soc. 2016, 138, 15877.



 Patel, H. H.; Sigman, M.S.* "Enantioselective Palladium-Catalyzed Alkenylation of Trisubstituted Alkenols to Form Allylic Quaternary Centers,"J. Am. Chem. Soc. 2016,138, 14226. 


 Santiago, C. B.; Milo, A; Sigman, M. S.* "Developing a Modern Approach To Account for Steric Effects in Hammett-Type Correlations," J. Am. Chem. Soc. 2016, 138, 13424.



 Chen, Z.-M.; Hilton, M. J.; Sigman, M. S.* "Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols," J. Am. Chem. Soc. 2016138, 11461.

zhi min TOC

 Niemeyer, Z.; Milo, A.; Hickey, D. P.; Sigman, M. S.* "Parameterization of phosphine ligands reveals mechanistic pathways and predicts reaction outcomes," Nature Chem20168, 610–617.

Zach paper


Related Websites

Department of Chemistry

Seminar Schedule

University of Utah

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Contact Information

Matthew S. Sigman
315 So. 1400 E. Rm. 4253A
Salt Lake City, UT 84112
Office: (801) 585-0774

Group News

Nick Race's report in JACS was featured in Organic Chemistry Highlights .

The Sigman group's work in collaboration with the Sanford group on redox-active electrolytes for flow batteries was featured on the cover of JACS and was highlighted in C&E News.

The Sigman group's work on non-covalent interactions was discussed in Forbes.

Nick Race's report in JACS was highlighted in Synfacts.

Harsh Patel's report in JACS was highlighted in Synfacts.

Matthew Sigman is featured in C&E News for receiving the ACS award for creative work in synthetic organic chemistry.

Nick Race's report in JACS was highlighted in C&E News

Celine Santiago’s report in JACS was highlighted in JACS Spotlights. 

Anat Milo’s report in JACS was highlighted in JACS Spotlights. 

David Hickey and David Schiedler's report in JACS was highlighted in JACS Spotlights. 

Tian-Sheng Mei and Harsh Patel's report in Nature was highlighted:News and Views: Morken, J. P. “Catalysis Marches On,” Nature 2014, 508, 324-325;Highlighted:Chem. & Eng. News 2014, 92 (15), 6.
Anat Milo's report in Nature was featured on the University of Utah website, in C&E News, and on the following science websites: Science360,, Eureka! Science News, Science 2.0, Laboratory Equipment, Science Codex, EurekAlert, Phys.Org, Newswise, Chemicals Technology, Daily News.
The Sigman group put together a short video about why they love chemistry!
Last Updated: 7/6/17