Asymmetric Catalysis, Organometallic Chemistry & Organic Synthesis

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Recent Research Highlights


Crawford, J. M.; Sigman, M. S."Conformational Dynamics in Asymmetric Catalysis: Is Catalyst Flexibility a Design Element?" Synthesis DOI: 10.1055/s-0037-1611636

Hickey, D. P.; Sandford, C.; Rhodes, Z.; Gensch, T.; Fries, L. R.; Sigman, M. S.; Minteer, S. D. "Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low Valent Co(I) Intermediates" J. Am. Chem. Soc.2019 DOI: 10.1021/jacs.8b12634

Mack, J. B. C.; Walker, K. L.; Robinson, S. G.; Zare, R. N.; Sigman, M. S.; Waymouth, R. M.; Du Bois, J. "Mechanistic Study of Ruthenium-Catalyzed C−H Hydroxylation Reveals an Unexpected Pathway for Catalyst Arrest" J. Am. Chem. Soc.2019, DOI: 10.1021/jacs.8b10950




Albright, H.; Riehl, P. S.; McAtee, C. C.; Reid, J. P.; Ludwig, J. R.; Karp, L.; Zimmerman, P. M.; Sigman, M. S.; Schindler, C. S. "Catalytic Carbonyl-Olefin Metathesis of Aliphatic Ketones: Iron(III) Homo-Dimers as Lewis Acidic Superelectrophiles" J. Am. Chem. Soc.2018 DOI: 10.1021/jacs.8b11840

 Vaden, R. M.; Guillen, K. P.; Salvant, J. M.; Santiago, C. B.; Gibbons, J. B.; Pathi, S. S.; Arunachalam, S.; Sigman, M. S.; Looper, R. E.; Welm, B. E. "A cancer-selective zinc ionophore inspired by the natural product naamidine A" ACS Chemical Biology2018 DOI: 10.1021/acschembio.8b00977

Race, N.; Yuan, Q.; Sigman, M. S. "Enantioselective C2‐alkylation of indoles via a redox‐relay Heck reaction of 2‐indole triflates" Chem. Eur. J.2018, 10.1002/chem.201805416

Zhao, S.; Gensch, T.; Murray, B.; Niemeyer, Z. L.; Sigman, M. S.; Biscoe, M. R."Enantiodivergent Pd-catalyzed C–C bond formation enabled through ligand parameterization" Science2018, 362, 670


Coelho, J. A. S.; Matsumoto, A.; Orlandi, M.; Hilton, M. J.; Sigman, M. S.; Toste, F. D. "Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions" Chem. Sci.2018 DOI :10.1039/C8SC02223B.

fluoro pub

Metsänen, T. T.; Lexa, K. W.; Santiago, C. B.; Chung, C. K.; Xu, Y.; Liu, Z.; Humphrey, G. R.; Ruck, R. T.; Sherer, E. C.; Sigman, M. S."Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir)"Chem. Sci.2018, 9, 6922.


 Yuan, Q.; Sigman, M. S. "Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams" J. Am. Chem. Soc. 2018, 140, 6527.

q pub

Patel, H. H.; Prater, M. B.; Squire, S. O.; Sigman, M.S.* "Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers"  J. Am. Chem. Soc. 140, 5895.

harsh pub

Crawford, J. M.; Stone, E. A.; Metrano, A. J.; Miller, S. J.; Sigman, M. S. "Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of 3‐Arylquinazolin-4(3H)‐ones" J. Am. Chem. Soc.2018, 140, 868.


Biswas, S.; Kubota, K.; Orlandi, M.; Turberg, M.; Miles, D. H.; Sigman, M. S.; Toste, F. D. "Enantioselective Synthesis of N,S-Acetals by an Oxidative Pummerer-Type Transformation using Phase-Transfer Catalysis"Angew. Chem. Int. Ed., 2018, 57 589. 



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Matthew S. Sigman
315 So. 1400 E. Rm. 4253A
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Office: (801) 585-0774

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Group News

Tobias Gensch's Science paper was highlighted in UNEWS

Congratulations to Nicholas Race for becoming the newest faculty member at Univerisy of Minnesota in the department of Chemistry! 

Congratulations to Rachel Vaden for her new position at Pfizer as a  research scientist in the cancer drug discovery group!

Congratulations to Elizabeth Bess for becoming the newest faculty member at UC-Irivine  in Chemical Biology!

Yoonsu Park's work in collaboration with Zach Niemeyer from the Sigman lab  was featured on the cover of Organometallics.

The Sigman group's work in collaboration with the Doyle group was highlighted as Synfact of the Month!

Nick Race's report in JACS was featured in Organic Chemistry Highlights .

The Sigman group's work in collaboration with the Sanford group on redox-active electrolytes for flow batteries was featured on the cover of JACS and was highlighted in C&E News.

The Sigman group's work on non-covalent interactions was discussed in Forbes.

Nick Race's report in JACS was highlighted in Synfacts.

Harsh Patel's report in JACS was highlighted in Synfacts.

Matthew Sigman is featured in C&E News for receiving the ACS award for creative work in synthetic organic chemistry.

Nick Race's report in JACS was highlighted in C&E News

Celine Santiago’s report in JACS was highlighted in JACS Spotlights. 

Anat Milo’s report in JACS was highlighted in JACS Spotlights. 

David Hickey and David Schiedler's report in JACS was highlighted in JACS Spotlights. 

Tian-Sheng Mei and Harsh Patel's report in Nature was highlighted:News and Views: Morken, J. P. “Catalysis Marches On,” Nature 2014, 508, 324-325;Highlighted:Chem. & Eng. News 2014, 92 (15), 6.
Anat Milo's report in Nature was featured on the University of Utah website, in C&E News, and on the following science websites: Science360,, Eureka! Science News, Science 2.0, Laboratory Equipment, Science Codex, EurekAlert, Phys.Org, Newswise, Chemicals Technology, Daily News.
The Sigman group put together a short video about why they love chemistry!
Last Updated: 2/21/19