Recent Research Highlights
2019
Crawford, J. M.; Sigman, M. S."Conformational Dynamics in Asymmetric Catalysis: Is Catalyst Flexibility a Design Element?" Synthesis DOI: 10.1055/s-0037-1611636
Hickey, D. P.; Sandford, C.; Rhodes, Z.; Gensch, T.; Fries, L. R.; Sigman, M. S.; Minteer, S. D. "Investigating the Role of Ligand Electronics on Stabilizing Electrocatalytically Relevant Low Valent Co(I) Intermediates" J. Am. Chem. Soc.2019 DOI: 10.1021/jacs.8b12634
Mack, J. B. C.; Walker, K. L.; Robinson, S. G.; Zare, R. N.; Sigman, M. S.; Waymouth, R. M.; Du Bois, J. "Mechanistic Study of Ruthenium-Catalyzed C−H Hydroxylation Reveals an Unexpected Pathway for Catalyst Arrest" J. Am. Chem. Soc.2019, DOI: 10.1021/jacs.8b10950
2018
Albright, H.; Riehl, P. S.; McAtee, C. C.; Reid, J. P.; Ludwig, J. R.; Karp, L.; Zimmerman, P. M.; Sigman, M. S.; Schindler, C. S. "Catalytic Carbonyl-Olefin Metathesis of Aliphatic Ketones: Iron(III) Homo-Dimers as Lewis Acidic Superelectrophiles" J. Am. Chem. Soc.2018 DOI: 10.1021/jacs.8b11840
Vaden, R. M.; Guillen, K. P.; Salvant, J. M.; Santiago, C. B.; Gibbons, J. B.; Pathi, S. S.; Arunachalam, S.; Sigman, M. S.; Looper, R. E.; Welm, B. E. "A cancer-selective zinc ionophore inspired by the natural product naamidine A" ACS Chemical Biology2018 DOI: 10.1021/acschembio.8b00977
Race, N.; Yuan, Q.; Sigman, M. S. "Enantioselective C2‐alkylation of indoles via a redox‐relay Heck reaction of 2‐indole triflates" Chem. Eur. J.2018, 10.1002/chem.201805416
Zhao, S.; Gensch, T.; Murray, B.; Niemeyer, Z. L.; Sigman, M. S.; Biscoe, M. R."Enantiodivergent Pd-catalyzed C–C bond formation enabled through ligand parameterization" Science2018, 362, 670
Coelho, J. A. S.; Matsumoto, A.; Orlandi, M.; Hilton, M. J.; Sigman, M. S.; Toste, F. D. "Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions" Chem. Sci.2018 DOI :10.1039/C8SC02223B.
Metsänen, T. T.; Lexa, K. W.; Santiago, C. B.; Chung, C. K.; Xu, Y.; Liu, Z.; Humphrey, G. R.; Ruck, R. T.; Sherer, E. C.; Sigman, M. S."Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir)"Chem. Sci.2018, 9, 6922.
Yuan, Q.; Sigman, M. S. "Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams" J. Am. Chem. Soc. 2018, 140, 6527.
Patel, H. H.; Prater, M. B.; Squire, S. O.; Sigman, M.S.* "Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers" J. Am. Chem. Soc. 140, 5895.
Crawford, J. M.; Stone, E. A.; Metrano, A. J.; Miller, S. J.; Sigman, M. S. "Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of 3‐Arylquinazolin-4(3H)‐ones" J. Am. Chem. Soc.2018, 140, 868.
Biswas, S.; Kubota, K.; Orlandi, M.; Turberg, M.; Miles, D. H.; Sigman, M. S.; Toste, F. D. "Enantioselective Synthesis of N,S-Acetals by an Oxidative Pummerer-Type Transformation using Phase-Transfer Catalysis"Angew. Chem. Int. Ed., 2018, 57 589.
