Recent Research Highlights
Zhao, S.; Gensch, T.; Murray, B.; Niemeyer, Z. L.; Sigman, M. S.; Biscoe, M. R."Enantiodivergent Pd-catalyzed C–C bond formation enabled through ligand parameterization" Science2018. DOI: 10.1126/science.aat2299
Coelho, J. A. S.; Matsumoto, A.; Orlandi, M.; Hilton, M. J.; Sigman, M. S.; Toste, F. D. "Enantioselective fluorination of homoallylic alcohols enabled by the tuning of non-covalent interactions" Chem. Sci.2018 DOI :10.1039/C8SC02223B.
Metsänen, T. T.; Lexa, K. W.; Santiago, C. B.; Chung, C. K.; Xu, Y.; Liu, Z.; Humphrey, G. R.; Ruck, R. T.; Sherer, E. C.; Sigman, M. S."Combining traditional 2D and modern physical organic-derived descriptors to predict enhanced enantioselectivity for the key aza-Michael conjugate addition in the synthesis of Prevymis™ (letermovir)"Chem. Sci.2018, 9, 6922.
Yuan, Q.; Sigman, M. S. "Palladium-Catalyzed Enantioselective Relay Heck Arylation of Enelactams: Accessing α,β-Unsaturated δ-Lactams" J. Am. Chem. Soc. 2018, 140, 6527.
Patel, H. H.; Prater, M. B.; Squire, S. O.; Sigman, M.S.* "Formation of Chiral Allylic Ethers via an Enantioselective Palladium-Catalyzed Alkenylation of Acyclic Enol Ethers" J. Am. Chem. Soc. 140, 5895.
Crawford, J. M.; Stone, E. A.; Metrano, A. J.; Miller, S. J.; Sigman, M. S. "Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of 3‐Arylquinazolin-4(3H)‐ones" J. Am. Chem. Soc.2018, 140, 868.
Biswas, S.; Kubota, K.; Orlandi, M.; Turberg, M.; Miles, D. H.; Sigman, M. S.; Toste, F. D. "Enantioselective Synthesis of N,S-Acetals by an Oxidative Pummerer-Type Transformation using Phase-Transfer Catalysis"Angew. Chem. Int. Ed., 2018, 57 589.
