Recent Research Highlights
Crawford, J. M.; Stone, E. A.; Metrano, A. J.; Miller, S. J.; Sigman, M. S. "Parameterization and Analysis of Peptide-Based Catalysts for the Atroposelective Bromination of 3‐Arylquinazolin-4(3H)‐ones" J. Am. Chem. Soc.2018, 140, 868.
Biswas, S.; Kubota, K.; Orlandi, M.; Turberg, M.; Miles, D. H.; Sigman, M. S.; Toste, F. D. "Enantioselective Synthesis of N,S-Acetals by an Oxidative Pummerer-Type Transformation using Phase-Transfer Catalysis"Angew. Chem. Int. Ed.,
Bischoff, A. J.; Nelson, B. M.; Niemeyer, Z. L.; Sigman, M. S.; Movassaghi, M."Quantitative Modeling of Bis(pyridine)silver(I) Permanganate Oxidation of Hydantoin Derivatives: Guidelines for Predicting the Site of Oxidation in Complex Substrates" J. Am. Chem. Soc.2017. DOI: 10.1021/jacs.7b09541
Engl, P. S.; Santiago, C. B.; Gordon, C. P.; Liao, W.-C.; Fedorov, A.; Copéret, C.; Sigman, M. S.; Togni, A. "Exploiting and Understanding the Selectivity of Ru-N-Heterocyclic Carbene Metathesis Catalysts for the Ethenolysis of Cyclic Olefins to α,ω-Dienes" J. Am. Chem. Soc. 2017, 139, 13117.
Orlandi, M.; Hilton, M. J.; Yamamoto, E.; Toste, F. D.; Sigman, M. S. "Mechanistic Investigations of the Pd(0)-Catalyzed Enantioselective 1,1-Diarylation of Benzyl Acrylates" J. Am. Chem. Soc.2017, 139, 12688.
Niemeyer, Z. L.; Pindi, S.; Khrakovsky, D. A.; Kuzniewski, C. N.; Hong, C. M.; Joyce, L. A.; Sigman, M. S.; Toste, F. D. "Parameterization of Acyclic Diaminocarbene Ligands Applied to a Gold(I)-Catalyzed Enantioselective Tandem Rearrangement/Cyclization" J. Am. Chem. Soc.2017, 139, 12943.
Keylor, M. H.; Niemeyer, Z. L.; Sigman, M. S.; Tan, K. L."Inverting Conventional Chemoselectivity in Pd-Catalyzed Amine Arylations with Multiply Halogenated Pyridines" J. Am. Chem. Soc.2017, 139, 10613.
Guo, J.-Y.; Minko, Y.; Santiago, C. B.; Sigman, M. S. "Developing Comprehensive Computational Parameter Sets To Describe the Performance of Pyridine-Oxazoline and Related Ligands" ACS Catal. 2017, 7, 4144.
Mack, J. B. C.; Gipson, J. D.; Du Bois, J.; Sigman, M. S. "Ruthenium-Catalyzed C–H Hydroxylation in Aqueous Acid Enables Selective Functionalization of Amine Derivatives" J. Am. Chem. Soc.2017 139, 9503.
Plata, R. E.; Hill, D. E.; Haines, B. E.; Musaev, D. G.; Chu, L.; Hickey, D. P.; Sigman, M. S.; Yu, J.-Q.; Blackmond, D. G. "A Role for Pd(IV) in Catalytic Enantioselective C–H Functionalization with Monoprotected Amino Acid Ligands under Mild Conditions" J. Am. Chem. Soc.2017, 139, 9238.
Orlandi, M.; Coelho, J. A. S.; Hilton, M. J.; Toste, F. D.; Sigman, M. S. "Parametrization of Non-covalent Interactions for Transition State Interrogation Applied to Asymmetric Catalysis" J. Am. Chem. Soc.2017, 139, 6803.
Christian, A. H.; Niemeyer, Z. L.; Sigman, M. S.; Toste, F. D. "Uncovering Subtle Ligand Effects of Phosphines Using Gold(I) Catalysis" ACS Catal. 2017, 3973.
Avila, C. M.; Patel, J. S.; Reddi, Y.; Saito, M.; Nelson, H. M.; Shunatona, H. P.; Sigman, M. S.; Sunoj, R. B.; Toste, F. D. "Enantioselective Heck–Matsuda Arylations through Chiral Anion Phase-Transfer of Aryl Diazonium Salts" Angew. Chem. Int. Ed.2017, 56. 5806.
Chen, Z.-M.; Nervig, C. S.; DeLuca, R. J.; Sigman, M. S.* "Palladium-Catalyzed Enantioselective Redox-Relay Heck Alkynylation of Alkenols to Access Propargylic Stereocenters” Angew. Chem. Int. Ed.2017, 56, 1.
B. P. Woods, M. Orlandi, C.-Y. Huang, M. S. Sigman, A. G. Doyle, J. Am. Chem. Soc. 2017 DOI: 10.1021/jacs.7b03448
F. D. Toste, M. S. Sigman, S. J. Miller"Pursuit of Noncovalent Interactions for Strategic Site-Selective Catalysis" Acc. Chem. Res. 2017, 50, 609.
A. J. Neel, M. J. Hilton, M. S. Sigman, F. D. Toste "Exploiting non-covalent π interactions for catalyst design" Nature 2017, 543, 637.
Sevov, C. S.; Hickey, D. P.; Cook, M. E.; Robinson, S. G.; Barnett, S.; Minteer, S. D.*; Sigman, M. S.*; Sanford, M. S.* " Physical Organic Approach to Persistent, Cyclable, Low-Potential Electrolytes for Flow Battery Applications,"J. Am. Chem. Soc. 2017, 139, 2924.
Zhang, C.; Tutkowski, B.; DeLuca, R. J.; Joyce, L. A. Wiest, O.; Sigman, M. S.* "Palladium-catalyzed enantioselective Heck alkenylation of trisubstituted allylic alkenols: a redox-relay strategy to construct vicinal stereocenters," Chem. Sci. 2017, 8, 2277.
