Asymmetric Catalysis, Organometallic Chemistry & Organic Synthesis



group retreat 2016 2


Recent Research Highlights


Patel, H. H.; Sigman, M.S.* "Enantioselective Palladium-Catalyzed Alkenylation of Trisubstituted Alkenols to Form Allylic Quaternary Centers," J. Am. Chem. Soc. 2016.DOI: 10.1021/jacs.6b09649


 Santiago, C. B.; Milo, A; Sigman, M. S.* "Developing a Modern Approach To Account for Steric Effects in Hammett-Type Correlations," J. Am. Chem. Soc. 2016DOI: 10.1021/jacs.6b08799.



 Chen, Z.-M.; Hilton, M. J.; Sigman, M. S.* "Palladium-Catalyzed Enantioselective Redox-Relay Heck Arylation of 1,1-Disubstituted Homoallylic Alcohols," J. Am. Chem. Soc. 2016138, 11461.

zhi min TOC

 Niemeyer, Z.; Milo, A.; Hickey, D. P.; Sigman, M. S.* "Parameterization of phosphine ligands reveals mechanistic pathways and predicts reaction outcomes," Nature Chem20168, 610–617.

Zach paper

 Zhang, C.; Santiago, C. B.; Crawford, J. M.; Sigman, M. S.* “Enantioselective Dehydrogenative Heck Arylations of Trisubstituted Alkenes with Indoles to Construct Quaternary Stereocenters,” J. Am. Chem. Soc. 2015, 137, 15668.


 Hickey, D. P.; Schiedler, D. A.; Matanovic, I.;Doan, P. V.; Atanassov, P.; Minteer, S. D.*; Sigman, M. S.* “Predicting Electrocatalytic Properties: Modeling Structure-Activity Relationships of Nitroxyl Radicals,” J. Am. Chem. Soc. 2015, 137, 16179-16186.


 Hickey, D. P.; Milton, R. D.; Chen, R.; Sigman, M. S.*; Minteer, S. D.* “TEMPO-Modified Linear Poly(ethylenimine) for Immobilization-Enhanced Electrocatalytic Oxidation of Alcohols,” ACS Catalysis 2015, 5, 5519-5524.



Zhang, C.; Santiago, C. B.; Kou, L.; Sigman, M. S.* “Alkenyl Carbonyl Derivatives in Enantioselective Redox Relay Heck Reactions: Accessing α,β-Unsaturated Systems,” J. Am Chem. Soc. 2015, 137, 7290-7293.


 Mougel, V.; Santiago, C. B.; Zhizhko, P. A.; Bess, E. N.; Varga, J.; Frater, G.; Sigman, M. S.; Copéret, C. “Quantitatively Analyzing Metathesis Catalyst Activity and Structural Features in Silica-Supported Tungsten Imido–Alkylidene Complexes,” J. Am. Chem. Soc. 2015, 137, 6699-6704.


Saini, V.; O’Dair, M. §; Sigman, M. S.* “Synthesis of Highly Functionalized Tri-and Tetrasubstituted Alkenes via Pd-Catalyzed 1,2-Hydrovinylation of Terminal 1,3-Dienes,” J. Am. Chem. Soc. 2015, 137, 608-611.





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Contact Information

Matthew S. Sigman
315 So. 1400 E. Rm. 4253A
Salt Lake City, UT 84112
Office: (801) 585-0774

Group News

Anat Milo’s report in JACS was highlighted in JACS Spotlights.

David Hickey and David Schiedler's report in JACS was highlighted in JACS Spotlights.

Congrats to previous Sigman group members for their recent jobs: Erik Werner (Gilead), Brian Michel (U. of Denver), & Kara Stowers (BYU)
Congratulations to Tian-Sheng Mei for accepting an offer at SIOC to begin his academic career.
Congratulations to Ben Stokes for accepting an offer at UC Merced to begin his academic career.
Congratulations to Ryan De Luca for completing his Ph.D. and moving to Justin Du Bois' lab for a postdoc.
Tian-Sheng Mei and Harsh Patel's report in Nature was highlighted:News and Views: Morken, J. P. “Catalysis Marches On,” Nature 2014, 508, 324-325;Highlighted:Chem. & Eng. News 2014, 92 (15), 6.
Anat Milo's report in Nature was featured on the University of Utah website, in C&E News, and on the following science websites: Science360,, Eureka! Science News, Science 2.0, Laboratory Equipment, Science Codex, EurekAlert, Phys.Org, Newswise, Chemicals Technology, Daily News.
The Sigman group put together a short video about why they love chemistry!
Last Updated: 10/27/16